BRD-A94756469_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

180 genes differentially expressed following the BRD-A94756469_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ANO1 anoctamin 1, calcium activated chloride channel
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BTG2 BTG family, member 2
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
COL11A1 collagen, type XI, alpha 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DEPTOR DEP domain containing MTOR-interacting protein
DHCR24 24-dehydrocholesterol reductase
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EZR ezrin
FBN2 fibrillin 2
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GLS glutaminase
H1F0 H1 histone family, member 0
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IER2 immediate early response 2
IER3 immediate early response 3
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KDM6B lysine (K)-specific demethylase 6B
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
LRRC15 leucine rich repeat containing 15
LTBP2 latent transforming growth factor beta binding protein 2
MAGEA3 melanoma antigen family A3
MCL1 myeloid cell leukemia 1
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
NACA nascent polypeptide-associated complex alpha subunit
NET1 neuroepithelial cell transforming 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPL1 nucleoporin like 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGS1 regulator of G-protein signaling 1
RGS13 regulator of G-protein signaling 13
RGS2 regulator of G-protein signaling 2
RPL37A ribosomal protein L37a
SAT1 spermidine/spermine N1-acetyltransferase 1
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC26A3 solute carrier family 26 (anion exchanger), member 3
TCL1A T-cell leukemia/lymphoma 1A
TFF3 trefoil factor 3 (intestinal)
TFRC transferrin receptor
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRA2A transformer 2 alpha homolog (Drosophila)
TSC22D2 TSC22 domain family, member 2
TSPAN13 tetraspanin 13
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UGCG UDP-glucose ceramide glucosyltransferase
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACD adrenocortical dysplasia homolog (mouse)
ADCY1 adenylate cyclase 1 (brain)
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AIM1 absent in melanoma 1
ANXA4 annexin A4
APOD apolipoprotein D
ARL4C ADP-ribosylation factor-like 4C
ATF5 activating transcription factor 5
ATMIN ATM interactor
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX4 brain expressed, X-linked 4
C2ORF68 chromosome 2 open reading frame 68
C3 complement component 3
C6ORF62 chromosome 6 open reading frame 62
CBR1 carbonyl reductase 1
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCND2 cyclin D2
CFB complement factor B
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DMXL1 Dmx-like 1
DPP4 dipeptidyl-peptidase 4
DUSP4 dual specificity phosphatase 4
FGB fibrinogen beta chain
FN1 fibronectin 1
FRZB frizzled-related protein
GJA1 gap junction protein, alpha 1, 43kDa
GLDC glycine dehydrogenase (decarboxylating)
GLRX glutaredoxin (thioltransferase)
HGD homogentisate 1,2-dioxygenase
HMGA2 high mobility group AT-hook 2
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HRSP12 heat-responsive protein 12
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IRAK3 interleukin-1 receptor-associated kinase 3
IRS2 insulin receptor substrate 2
ITGA6 integrin, alpha 6
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KLK3 kallikrein-related peptidase 3
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LINC00341 long intergenic non-protein coding RNA 341
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MKKS McKusick-Kaufman syndrome
MMP7 matrix metallopeptidase 7
MSLN mesothelin
MSMB microseminoprotein, beta-
MTDH metadherin
NFIB nuclear factor I/B
NMI N-myc (and STAT) interactor
NPTXR neuronal pentraxin receptor
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRCAM neuronal cell adhesion molecule
NUP62 nucleoporin 62kDa
PDE4B phosphodiesterase 4B, cAMP-specific
PDZK1IP1 PDZK1 interacting protein 1
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PURA purine-rich element binding protein A
QPCT glutaminyl-peptide cyclotransferase
RAP1GAP2 RAP1 GTPase activating protein 2
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RHOBTB3 Rho-related BTB domain containing 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS4Y1 ribosomal protein S4, Y-linked 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SLC35E2B solute carrier family 35, member E2B
SNX10 sorting nexin 10
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SPTSSA serine palmitoyltransferase, small subunit A
TF transferrin
TFPI2 tissue factor pathway inhibitor 2
TJP2 tight junction protein 2
TMEM47 transmembrane protein 47
TMX4 thioredoxin-related transmembrane protein 4
TRAPPC3 trafficking protein particle complex 3
TRIM14 tripartite motif containing 14
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZC3H4 zinc finger CCCH-type containing 4
ZNF185 zinc finger protein 185 (LIM domain)