BRD-A94756469_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

200 genes differentially expressed following the BRD-A94756469_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR1C3 aldo-keto reductase family 1, member C3
ANXA3 annexin A3
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BHLHE40 basic helix-loop-helix family, member e40
BRD4 bromodomain containing 4
BTG3 BTG family, member 3
CAV2 caveolin 2
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC5A C-type lectin domain family 5, member A
CPM carboxypeptidase M
CREM cAMP responsive element modulator
CST6 cystatin E/M
CTGF connective tissue growth factor
CTSC cathepsin C
CXADR coxsackie virus and adenovirus receptor
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DHCR7 7-dehydrocholesterol reductase
DLX2 distal-less homeobox 2
DPT dermatopontin
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EGR1 early growth response 1
ELOVL4 ELOVL fatty acid elongase 4
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM60A family with sequence similarity 60, member A
FGFBP1 fibroblast growth factor binding protein 1
FNDC3B fibronectin type III domain containing 3B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GDE1 glycerophosphodiester phosphodiesterase 1
GPNMB glycoprotein (transmembrane) nmb
GSTP1 glutathione S-transferase pi 1
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IER2 immediate early response 2
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
IL13RA2 interleukin 13 receptor, alpha 2
IRF6 interferon regulatory factor 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KDM6B lysine (K)-specific demethylase 6B
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KLK5 kallikrein-related peptidase 5
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
LUM lumican
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MCL1 myeloid cell leukemia 1
MEG3 maternally expressed 3 (non-protein coding)
MMP10 matrix metallopeptidase 10
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRG1 neuregulin 1
NRIP1 nuclear receptor interacting protein 1
NUPL1 nucleoporin like 1
NXN nucleoredoxin
OSR2 odd-skipped related transciption factor 2
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PALLD palladin, cytoskeletal associated protein
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PNKP polynucleotide kinase 3'-phosphatase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RGS2 regulator of G-protein signaling 2
RND3 Rho family GTPase 3
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SDC2 syndecan 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOX4 SRY (sex determining region Y)-box 4
STOM stomatin
TBX3 T-box 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMSB15A thymosin beta 15a
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
WEE1 WEE1 G2 checkpoint kinase
WISP2 WNT1 inducible signaling pathway protein 2
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD3 adducin 3 (gamma)
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANXA6 annexin A6
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ATMIN ATM interactor
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
B3GNT1
BRCA1 breast cancer 1, early onset
C2CD5 C2 calcium-dependent domain containing 5
C3 complement component 3
C6ORF62 chromosome 6 open reading frame 62
CANT1 calcium activated nucleotidase 1
CBR3 carbonyl reductase 3
CFB complement factor B
CHL1 cell adhesion molecule L1-like
CPE carboxypeptidase E
CRISP3 cysteine-rich secretory protein 3
CSK c-src tyrosine kinase
CX3CR1 chemokine (C-X3-C motif) receptor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EBAG9 estrogen receptor binding site associated, antigen, 9
FANCF Fanconi anemia, complementation group F
FGF1 fibroblast growth factor 1 (acidic)
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
INTS3 integrator complex subunit 3
ITGB1BP1 integrin beta 1 binding protein 1
LONP2 lon peptidase 2, peroxisomal
MAP2K6 mitogen-activated protein kinase kinase 6
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MEIS1 Meis homeobox 1
METTL13 methyltransferase like 13
NMRK1 nicotinamide riboside kinase 1
NREP neuronal regeneration related protein
PCYOX1L prenylcysteine oxidase 1 like
PDS5A PDS5 cohesin associated factor A
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCA protein kinase C, alpha
PRR7 proline rich 7 (synaptic)
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RAB15 RAB15, member RAS oncogene family
RAB29 RAB29, member RAS oncogene family
RNASET2 ribonuclease T2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100B S100 calcium binding protein B
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPT9 septin 9
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SPDEF SAM pointed domain containing ETS transcription factor
SPINK1 serine peptidase inhibitor, Kazal type 1
SRGN serglycin
SRPX sushi-repeat containing protein, X-linked
STAMBP STAM binding protein
STEAP3 STEAP family member 3, metalloreductase
TBC1D31 TBC1 domain family, member 31
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TRAK2 trafficking protein, kinesin binding 2
TSEN2 TSEN2 tRNA splicing endonuclease subunit
USP34 ubiquitin specific peptidase 34
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
XBP1 X-box binding protein 1
XPOT exportin, tRNA
ZNF185 zinc finger protein 185 (LIM domain)
ZNF302 zinc finger protein 302
ZNF32 zinc finger protein 32
ZNF512B zinc finger protein 512B
Funding