BRD-A97437073_Rosiglitazone_PC3_24.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

111 genes differentially expressed following the BRD-A97437073_Rosiglitazone_PC3_24.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAMBI BMP and activin membrane-bound inhibitor
BMP2 bone morphogenetic protein 2
BTG3 BTG family, member 3
CBS cystathionine-beta-synthase
CCL20 chemokine (C-C motif) ligand 20
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLCA4 chloride channel accessory 4
CRABP2 cellular retinoic acid binding protein 2
CRCT1 cysteine-rich C-terminal 1
CST1 cystatin SN
CTH cystathionine gamma-lyase
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DHRS9 dehydrogenase/reductase (SDR family) member 9
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
DYNLT1 dynein, light chain, Tctex-type 1
ECM1 extracellular matrix protein 1
EYA2 EYA transcriptional coactivator and phosphatase 2
FAM162A family with sequence similarity 162, member A
GARS glycyl-tRNA synthetase
HBEGF heparin-binding EGF-like growth factor
HMOX1 heme oxygenase 1
IGHM immunoglobulin heavy constant mu
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R2 interleukin 1 receptor, type II
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
INSIG1 insulin induced gene 1
ITGB5 integrin, beta 5
KCNK1 potassium channel, two pore domain subfamily K, member 1
KRT17 keratin 17, type I
KRT20 keratin 20, type I
KRT6A keratin 6A, type II
MFAP5 microfibrillar associated protein 5
MMP11 matrix metallopeptidase 11
MMP19 matrix metallopeptidase 19
MYC v-myc avian myelocytomatosis viral oncogene homolog
MZB1 marginal zone B and B1 cell-specific protein
NDRG1 N-myc downstream regulated 1
NPC1 Niemann-Pick disease, type C1
PI3 peptidase inhibitor 3, skin-derived
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPARD peroxisome proliferator-activated receptor delta
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKCD protein kinase C, delta
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RHCG Rh family, C glycoprotein
S100A12 S100 calcium binding protein A12
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPT6 septin 6
SERINC5 serine incorporator 5
SFN stratifin
SPRR2B small proline-rich protein 2B
STK10 serine/threonine kinase 10
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRIB3 tribbles pseudokinase 3
TSPAN3 tetraspanin 3
TSPAN7 tetraspanin 7
VEGFA vascular endothelial growth factor A
ZG16 zymogen granule protein 16

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANOS1 anosmin 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AXL AXL receptor tyrosine kinase
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CAV1 caveolin 1, caveolae protein, 22kDa
CCNB1 cyclin B1
CDH3 cadherin 3, type 1, P-cadherin (placental)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL9 chemokine (C-X-C motif) ligand 9
CYR61 cysteine-rich, angiogenic inducer, 61
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENO1 enolase 1, (alpha)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPRC5B G protein-coupled receptor, class C, group 5, member B
GRK5 G protein-coupled receptor kinase 5
H2AFX H2A histone family, member X
HIST1H2BK histone cluster 1, H2bk
HMGN3 high mobility group nucleosomal binding domain 3
HOXA10 homeobox A10
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
LGALS1 lectin, galactoside-binding, soluble, 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MDFIC MyoD family inhibitor domain containing
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MYOF myoferlin
NEBL nebulette
NRN1 neuritin 1
PAIP1 poly(A) binding protein interacting protein 1
PBK PDZ binding kinase
PON3 paraoxonase 3
PPARG peroxisome proliferator-activated receptor gamma
TEX10 testis expressed 10
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
Funding