BRD-K00088062_Tpl2_HCC515_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

61 genes differentially expressed following the BRD-K00088062_Tpl2_HCC515_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5 arachidonate 5-lipoxygenase
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
EAPP E2F-associated phosphoprotein
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
GADD45B growth arrest and DNA-damage-inducible, beta
GULP1 GULP, engulfment adaptor PTB domain containing 1
IGKV1-5 immunoglobulin kappa variable 1-5
JCHAIN joining chain of multimeric IgA and IgM
KDM5D lysine (K)-specific demethylase 5D
KRT7 keratin 7, type II
MAL mal, T-cell differentiation protein
MLANA melan-A
PMEL premelanosome protein
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
TYRP1 tyrosinase-related protein 1

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARL4C ADP-ribosylation factor-like 4C
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BMP4 bone morphogenetic protein 4
CHGB chromogranin B
CHRDL1 chordin-like 1
CPB1 carboxypeptidase B1 (tissue)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR2 early growth response 2
EPHA2 EPH receptor A2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FOSL1 FOS-like antigen 1
FSD1 fibronectin type III and SPRY domain containing 1
GLUL glutamate-ammonia ligase
HBEGF heparin-binding EGF-like growth factor
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
MMP9 matrix metallopeptidase 9
NPTX2 neuronal pentraxin II
NPY1R neuropeptide Y receptor Y1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PHLDA1 pleckstrin homology-like domain, family A, member 1
PPA1 pyrophosphatase (inorganic) 1
PTN pleiotrophin
RFTN1 raftlin, lipid raft linker 1
SFRP1 secreted frizzled-related protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STC1 stanniocalcin 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
XIST X inactive specific transcript (non-protein coding)
Funding