BRD-K00088062_Tpl2_SNGM_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

167 genes differentially expressed following the BRD-K00088062_Tpl2_SNGM_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABAT 4-aminobutyrate aminotransferase
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
C1QA complement component 1, q subcomponent, A chain
CACYBP calcyclin binding protein
CASP7 caspase 7, apoptosis-related cysteine peptidase
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CFB complement factor B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS2 CDC28 protein kinase regulatory subunit 2
CLGN calmegin
COL3A1 collagen, type III, alpha 1
CRYAB crystallin, alpha B
CTH cystathionine gamma-lyase
CXCL13 chemokine (C-X-C motif) ligand 13
DCN decorin
DDR2 discoidin domain receptor tyrosine kinase 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DENND1B DENN/MADD domain containing 1B
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFL6 EGF-like-domain, multiple 6
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5 eukaryotic translation initiation factor 5
FTH1 ferritin, heavy polypeptide 1
GCLM glutamate-cysteine ligase, modifier subunit
GPC3 glypican 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD1 interferon-related developmental regulator 1
IGFBP3 insulin-like growth factor binding protein 3
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
ITM2A integral membrane protein 2A
KDM5D lysine (K)-specific demethylase 5D
KLHL21 kelch-like family member 21
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LCN2 lipocalin 2
LGALS8 lectin, galactoside-binding, soluble, 8
MAOB monoamine oxidase B
MEIS2 Meis homeobox 2
MME membrane metallo-endopeptidase
NEFH neurofilament, heavy polypeptide
NELL2 NEL-like 2 (chicken)
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PBX1 pre-B-cell leukemia homeobox 1
PDZRN3 PDZ domain containing ring finger 3
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PIR pirin (iron-binding nuclear protein)
PSAT1 phosphoserine aminotransferase 1
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
S100P S100 calcium binding protein P
SCGB1D2 secretoglobin, family 1D, member 2
SCPEP1 serine carboxypeptidase 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SPATS2L spermatogenesis associated, serine-rich 2-like
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRGN serglycin
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM14A transmembrane protein 14A
TMEM97 transmembrane protein 97
TPD52L1 tumor protein D52-like 1
TPD52L2 tumor protein D52-like 2
TRAK2 trafficking protein, kinesin binding 2
VTCN1 V-set domain containing T cell activation inhibitor 1
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
AIM1 absent in melanoma 1
APLP2 amyloid beta (A4) precursor-like protein 2
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
BEX1 brain expressed, X-linked 1
BHLHE40 basic helix-loop-helix family, member e40
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CCND1 cyclin D1
CD81 CD81 molecule
CDC42 cell division cycle 42
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CNN3 calponin 3, acidic
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DCBLD2 discoidin, CUB and LCCL domain containing 2
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP3 epithelial membrane protein 3
EXOSC4 exosome component 4
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM60A family with sequence similarity 60, member A
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
FXYD2 FXYD domain containing ion transport regulator 2
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GRB14 growth factor receptor-bound protein 14
HES1 hes family bHLH transcription factor 1
HMGA2 high mobility group AT-hook 2
IER3 immediate early response 3
INHBA inhibin, beta A
JUN jun proto-oncogene
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KLF6 Kruppel-like factor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
NBN nibrin
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRGN neurogranin (protein kinase C substrate, RC3)
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PNMA2 paraneoplastic Ma antigen 2
PRSS3 protease, serine, 3
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RPS11 ribosomal protein S11
S100A11 S100 calcium binding protein A11
SDC4 syndecan 4
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SORBS3 sorbin and SH3 domain containing 3
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQRDL sulfide quinone reductase-like (yeast)
STC1 stanniocalcin 1
TAGLN2 transgelin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
VAMP8 vesicle-associated membrane protein 8
VCAN versican
WEE1 WEE1 G2 checkpoint kinase
XIST X inactive specific transcript (non-protein coding)
Funding