BRD-K00234327_RU 24969_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

148 genes differentially expressed following the BRD-K00234327_RU 24969_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AMDHD2 amidohydrolase domain containing 2
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
CALML3 calmodulin-like 3
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD24 CD24 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CHGB chromogranin B
CKB creatine kinase, brain
CRABP2 cellular retinoic acid binding protein 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CSTA cystatin A (stefin A)
CTBP2 C-terminal binding protein 2
CTNND1 catenin (cadherin-associated protein), delta 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCT dopachrome tautomerase
EPHA3 EPH receptor A3
EZR ezrin
FAM134B family with sequence similarity 134, member B
FGFR2 fibroblast growth factor receptor 2
FOLR1 folate receptor 1 (adult)
FOXF2 forkhead box F2
FRZB frizzled-related protein
GP2 glycoprotein 2 (zymogen granule membrane)
GSTA1 glutathione S-transferase alpha 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIST1H1C histone cluster 1, H1c
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HK2 hexokinase 2
HLA-B major histocompatibility complex, class I, B
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-F major histocompatibility complex, class I, F
HOPX HOP homeobox
HOXB2 homeobox B2
HSPA4 heat shock 70kDa protein 4
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGKV4-1 immunoglobulin kappa variable 4-1
IPO13 importin 13
JCHAIN joining chain of multimeric IgA and IgM
KLK5 kallikrein-related peptidase 5
LDOC1 leucine zipper, down-regulated in cancer 1
LTF lactotransferrin
MBOAT7 membrane bound O-acyltransferase domain containing 7
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MLPH melanophilin
MSMB microseminoprotein, beta-
MYH10 myosin, heavy chain 10, non-muscle
NOV nephroblastoma overexpressed
NR4A3 nuclear receptor subfamily 4, group A, member 3
NVL nuclear VCP-like
NXN nucleoredoxin
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEG10 paternally expressed 10
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PPAP2B phosphatidic acid phosphatase type 2B
PRUNE2 prune homolog 2 (Drosophila)
RAB21 RAB21, member RAS oncogene family
RAB26 RAB26, member RAS oncogene family
RAI14 retinoic acid induced 14
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF19B ring finger protein 19B
S100A7 S100 calcium binding protein A7
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLPI secretory leukocyte peptidase inhibitor
STC1 stanniocalcin 1
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
SYNGR1 synaptogyrin 1
TBXA2R thromboxane A2 receptor
TESK1 testis-specific kinase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD2 abhydrolase domain containing 2
ACACB acetyl-CoA carboxylase beta
AIF1 allograft inflammatory factor 1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA3 annexin A3
AREG amphiregulin
BMI1 BMI1 proto-oncogene, polycomb ring finger
BST2 bone marrow stromal cell antigen 2
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CD163 CD163 molecule
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GGPS1 geranylgeranyl diphosphate synthase 1
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
H1F0 H1 histone family, member 0
HOXC6 homeobox C6
IDS iduronate 2-sulfatase
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL6ST interleukin 6 signal transducer
LAMC2 laminin, gamma 2
LTBP1 latent transforming growth factor beta binding protein 1
LTBP3 latent transforming growth factor beta binding protein 3
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
NCBP2 nuclear cap binding protein subunit 2, 20kDa
NGRN neugrin, neurite outgrowth associated
PCDH9 protocadherin 9
PDGFC platelet derived growth factor C
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMEPA1 prostate transmembrane protein, androgen induced 1
RBM34 RNA binding motif protein 34
RGS2 regulator of G-protein signaling 2
RPS27L ribosomal protein S27-like
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
SQLE squalene epoxidase
SYNM synemin, intermediate filament protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS4 thrombospondin 4
TM9SF3 transmembrane 9 superfamily member 3
TNC tenascin C
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNS1 tensin 1
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TUBB2B tubulin, beta 2B class IIb
TXNDC9 thioredoxin domain containing 9
VCAN versican
ZCCHC24 zinc finger, CCHC domain containing 24
Funding