BRD-K00313977_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

62 genes differentially expressed following the BRD-K00313977_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AK4 adenylate kinase 4
ALCAM activated leukocyte cell adhesion molecule
ANOS1 anosmin 1
APOLD1 apolipoprotein L domain containing 1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AURKA aurora kinase A
BLNK B-cell linker
C6ORF62 chromosome 6 open reading frame 62
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLU clusterin
CTSV cathepsin V
CXADR coxsackie virus and adenovirus receptor
DUSP1 dual specificity phosphatase 1
EGR2 early growth response 2
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FHL1 four and a half LIM domains 1
GAL galanin/GMAP prepropeptide
GREM1 gremlin 1, DAN family BMP antagonist
HACD1 3-hydroxyacyl-CoA dehydratase 1
KLF4 Kruppel-like factor 4 (gut)
MAOB monoamine oxidase B
NR4A2 nuclear receptor subfamily 4, group A, member 2
NVL nuclear VCP-like
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RGS5 regulator of G-protein signaling 5
RPS11 ribosomal protein S11
S100A9 S100 calcium binding protein A9
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
TMOD1 tropomodulin 1
TOX3 TOX high mobility group box family member 3
WFS1 Wolfram syndrome 1 (wolframin)
ZBTB18 zinc finger and BTB domain containing 18
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
BEX1 brain expressed, X-linked 1
BPIFA1 BPI fold containing family A, member 1
CALB1 calbindin 1, 28kDa
CDCA4 cell division cycle associated 4
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FAM3C family with sequence similarity 3, member C
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
HEATR1 HEAT repeat containing 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
LYZ lysozyme
MAGEA12 melanoma antigen family A12
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
PAM peptidylglycine alpha-amidating monooxygenase
PTGES prostaglandin E synthase
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SRPX sushi-repeat containing protein, X-linked
STX1A syntaxin 1A (brain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)