BRD-K00313977_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-K00313977_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRF5 adhesion G protein-coupled receptor F5
AKAP8L A kinase (PRKA) anchor protein 8-like
ANOS1 anosmin 1
APLP2 amyloid beta (A4) precursor-like protein 2
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
AREG amphiregulin
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BASP1 brain abundant, membrane attached signal protein 1
BAX BCL2-associated X protein
BSG basigin (Ok blood group)
CDK19 cyclin-dependent kinase 19
CKM creatine kinase, muscle
COCH cochlin
CPM carboxypeptidase M
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTGF connective tissue growth factor
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
EGR2 early growth response 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
GPM6A glycoprotein M6A
H3F3B H3 histone, family 3B (H3.3B)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ICAM1 intercellular adhesion molecule 1
IFT57 intraflagellar transport 57
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KLK11 kallikrein-related peptidase 11
LAMP3 lysosomal-associated membrane protein 3
LPIN2 lipin 2
LSR lipolysis stimulated lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MARK4 MAP/microtubule affinity-regulating kinase 4
MCL1 myeloid cell leukemia 1
NID1 nidogen 1
NT5E 5'-nucleotidase, ecto (CD73)
PDGFA platelet-derived growth factor alpha polypeptide
PEG10 paternally expressed 10
PERP PERP, TP53 apoptosis effector
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RRAD Ras-related associated with diabetes
SESN1 sestrin 1
SFTPB surfactant protein B
SORBS1 sorbin and SH3 domain containing 1
SUN1 Sad1 and UNC84 domain containing 1
TDO2 tryptophan 2,3-dioxygenase
TKTL1 transketolase-like 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPM4 tropomyosin 4
TSPAN12 tetraspanin 12
UBE3B ubiquitin protein ligase E3B
WAC WW domain containing adaptor with coiled-coil
YBX3 Y box binding protein 3
YES1 YES proto-oncogene 1, Src family tyrosine kinase
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
AKR1C3 aldo-keto reductase family 1, member C3
ANXA10 annexin A10
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
AUTS2 autism susceptibility candidate 2
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CFD complement factor D (adipsin)
CTBP2 C-terminal binding protein 2
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCK deoxycytidine kinase
DDIT4 DNA-damage-inducible transcript 4
DENND2D DENN/MADD domain containing 2D
DKK1 dickkopf WNT signaling pathway inhibitor 1
EIF4B eukaryotic translation initiation factor 4B
EIF5 eukaryotic translation initiation factor 5
FCGBP Fc fragment of IgG binding protein
GABPB1 GA binding protein transcription factor, beta subunit 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GOLGA8H golgin A8 family, member H
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HOXA5 homeobox A5
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
KIF14 kinesin family member 14
KLHL9 kelch-like family member 9
KRT19 keratin 19, type I
LRRC16A leucine rich repeat containing 16A
LYZ lysozyme
MAT2A methionine adenosyltransferase II, alpha
MATN2 matrilin 2
METTL7A methyltransferase like 7A
MT1F metallothionein 1F
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDE1 nudE neurodevelopment protein 1
NQO1 NAD(P)H dehydrogenase, quinone 1
OLFML3 olfactomedin-like 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PROM1 prominin 1
PRR15L proline rich 15-like
PSCA prostate stem cell antigen
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPL10 ribosomal protein L10
S100A6 S100 calcium binding protein A6
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SORD sorbitol dehydrogenase
SRSF7 serine/arginine-rich splicing factor 7
TMEM97 transmembrane protein 97
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TP53I3 tumor protein p53 inducible protein 3
TPD52L1 tumor protein D52-like 1
TSKU tsukushi, small leucine rich proteoglycan
TUSC3 tumor suppressor candidate 3
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VCAM1 vascular cell adhesion molecule 1
XBP1 X-box binding protein 1
ZDHHC6 zinc finger, DHHC-type containing 6