BRD-K00317371_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

192 genes differentially expressed following the BRD-K00317371_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AK2 adenylate kinase 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AP3D1 adaptor-related protein complex 3, delta 1 subunit
ARL4C ADP-ribosylation factor-like 4C
C9ORF16 chromosome 9 open reading frame 16
CAPN2 calpain 2, (m/II) large subunit
CD36 CD36 molecule (thrombospondin receptor)
CES1 carboxylesterase 1
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CLEC11A C-type lectin domain family 11, member A
CLEC4A C-type lectin domain family 4, member A
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CST3 cystatin C
CSTA cystatin A (stefin A)
CXCL8 chemokine (C-X-C motif) ligand 8
DCN decorin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMP3 epithelial membrane protein 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPHX2 epoxide hydrolase 2, cytoplasmic
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FLOT1 flotillin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GLO1 glyoxalase I
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
GRN granulin
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
IDO1 indoleamine 2,3-dioxygenase 1
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
ISYNA1 inositol-3-phosphate synthase 1
KDM5D lysine (K)-specific demethylase 5D
LTF lactotransferrin
LUM lumican
NCF1C neutrophil cytosolic factor 1C pseudogene
NDRG1 N-myc downstream regulated 1
NDRG2 NDRG family member 2
NQO2 NAD(P)H dehydrogenase, quinone 2
NT5E 5'-nucleotidase, ecto (CD73)
ORM1 orosomucoid 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDZK1IP1 PDZK1 interacting protein 1
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POSTN periostin, osteoblast specific factor
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RNASE4 ribonuclease, RNase A family, 4
RNASE6 ribonuclease, RNase A family, k6
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
STEAP1 six transmembrane epithelial antigen of the prostate 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSC22D3 TSC22 domain family, member 3
VCAN versican
VEGFA vascular endothelial growth factor A
VIM vimentin

decreased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACTG2 actin, gamma 2, smooth muscle, enteric
ADNP activity-dependent neuroprotector homeobox
AGO2 argonaute RISC catalytic component 2
AKAP13 A kinase (PRKA) anchor protein 13
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
ARHGAP12 Rho GTPase activating protein 12
ARMT1 acidic residue methyltransferase 1
ATP9A ATPase, class II, type 9A
AURKA aurora kinase A
BAMBI BMP and activin membrane-bound inhibitor
BLM Bloom syndrome, RecQ helicase-like
BMPR1A bone morphogenetic protein receptor, type IA
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CD58 CD58 molecule
CDC25A cell division cycle 25A
CDK7 cyclin-dependent kinase 7
CEP350 centrosomal protein 350kDa
CHD9 chromodomain helicase DNA binding protein 9
CKS2 CDC28 protein kinase regulatory subunit 2
CNOT4 CCR4-NOT transcription complex, subunit 4
COL4A5 collagen, type IV, alpha 5
CTBP2 C-terminal binding protein 2
DAAM1 dishevelled associated activator of morphogenesis 1
DCLK1 doublecortin-like kinase 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ELF1 E74-like factor 1 (ets domain transcription factor)
ELMO1 engulfment and cell motility 1
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESR1 estrogen receptor 1
FABP7 fatty acid binding protein 7, brain
FAM208B family with sequence similarity 208, member B
FNDC3B fibronectin type III domain containing 3B
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
HIST1H2BG histone cluster 1, H2bg
HN1 hematological and neurological expressed 1
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF1R insulin-like growth factor 1 receptor
JMJD6 jumonji domain containing 6
KCNK1 potassium channel, two pore domain subfamily K, member 1
KIAA0485 uncharacterized LOC57235
KIF14 kinesin family member 14
KLHL9 kelch-like family member 9
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LARP4B La ribonucleoprotein domain family, member 4B
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK6 mitogen-activated protein kinase 6
MED13 mediator complex subunit 13
MGP matrix Gla protein
MKL2 MKL/myocardin-like 2
MTF2 metal response element binding transcription factor 2
MYH10 myosin, heavy chain 10, non-muscle
NCK1 NCK adaptor protein 1
NCOA3 nuclear receptor coactivator 3
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOL11 nucleolar protein 11
NOTCH2NL notch 2 N-terminal like
NRIP1 nuclear receptor interacting protein 1
NUP85 nucleoporin 85kDa
PIAS1 protein inhibitor of activated STAT, 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHA5 pleckstrin homology domain containing, family A member 5
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RNF111 ring finger protein 111
RUFY3 RUN and FYVE domain containing 3
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SASH1 SAM and SH3 domain containing 1
SEC62 SEC62 homolog (S. cerevisiae)
SETD5 SET domain containing 5
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMAD3 SMAD family member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFBR3 transforming growth factor, beta receptor III
TIAM1 T-cell lymphoma invasion and metastasis 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLK2 tousled-like kinase 2
TMEM135 transmembrane protein 135
TNS3 tensin 3
TRPS1 trichorhinophalangeal syndrome I
TSC22D2 TSC22 domain family, member 2
TSPAN14 tetraspanin 14
TUBD1 tubulin, delta 1
USP6NL USP6 N-terminal like
VGLL4 vestigial-like family member 4
ZHX2 zinc fingers and homeoboxes 2
ZMIZ1 zinc finger, MIZ-type containing 1
ZMYM2 zinc finger, MYM-type 2
ZNF292 zinc finger protein 292
Funding