BRD-K00366212_2-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-8-methoxyquinazolin-4-amine KUC106573N_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

184 genes differentially expressed following the BRD-K00366212_2-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-8-methoxyquinazolin-4-amine KUC106573N_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANXA6 annexin A6
BSG basigin (Ok blood group)
CALR calreticulin
CD200 CD200 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L2 chitinase 3-like 2
COL2A1 collagen, type II, alpha 1
COL6A2 collagen, type VI, alpha 2
CTSZ cathepsin Z
DUSP22 dual specificity phosphatase 22
ELANE elastase, neutrophil expressed
ERP29 endoplasmic reticulum protein 29
FABP5 fatty acid binding protein 5 (psoriasis-associated)
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IGLV2-23 immunoglobulin lambda variable 2-23
KDM6A lysine (K)-specific demethylase 6A
KLF6 Kruppel-like factor 6
LAMP1 lysosomal-associated membrane protein 1
MALL mal, T-cell differentiation protein-like
MAOA monoamine oxidase A
MEF2C myocyte enhancer factor 2C
MMP14 matrix metallopeptidase 14 (membrane-inserted)
NCAM1 neural cell adhesion molecule 1
NELL2 NEL-like 2 (chicken)
PRSS3 protease, serine, 3
PRUNE2 prune homolog 2 (Drosophila)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
S100P S100 calcium binding protein P
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERTAD2 SERTA domain containing 2
SMC1A structural maintenance of chromosomes 1A
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPRR3 small proline-rich protein 3
TCF4 transcription factor 4
TMPRSS11E transmembrane protease, serine 11E
TSPAN7 tetraspanin 7

decreased expression

Symbol Name
ACPP acid phosphatase, prostate
ADAM9 ADAM metallopeptidase domain 9
ADAMDEC1 ADAM-like, decysin 1
ADI1 acireductone dioxygenase 1
AGTR1 angiotensin II receptor, type 1
AIM1 absent in melanoma 1
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
AOX1 aldehyde oxidase 1
APOC1 apolipoprotein C-I
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ATF1 activating transcription factor 1
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BASP1 brain abundant, membrane attached signal protein 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C3 complement component 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CCL19 chemokine (C-C motif) ligand 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPU centromere protein U
CEP57 centrosomal protein 57kDa
CETN3 centrin, EF-hand protein, 3
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHEK1 checkpoint kinase 1
COL11A1 collagen, type XI, alpha 1
CP ceruloplasmin (ferroxidase)
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRYZ crystallin, zeta (quinone reductase)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL9 chemokine (C-X-C motif) ligand 9
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCN decorin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLD dihydrolipoamide dehydrogenase
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DST dystonin
DYNLT3 dynein, light chain, Tctex-type 3
EBNA1BP2 EBNA1 binding protein 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP4 fatty acid binding protein 4, adipocyte
FOSL2 FOS-like antigen 2
FZD6 frizzled class receptor 6
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GBAS glioblastoma amplified sequence
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GMNN geminin, DNA replication inhibitor
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GOLT1B golgi transport 1B
GPRC5B G protein-coupled receptor, class C, group 5, member B
HAT1 histone acetyltransferase 1
HBB hemoglobin, beta
HNMT histamine N-methyltransferase
HOXD1 homeobox D1
IFI16 interferon, gamma-inducible protein 16
IFNGR1 interferon gamma receptor 1
IGFBP7 insulin-like growth factor binding protein 7
ITGAV integrin, alpha V
KANK1 KN motif and ankyrin repeat domains 1
KCTD3 potassium channel tetramerization domain containing 3
KDM5D lysine (K)-specific demethylase 5D
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
KRT14 keratin 14, type I
KRT8 keratin 8, type II
L1CAM L1 cell adhesion molecule
LEPROT leptin receptor overlapping transcript
LUM lumican
LYPLA1 lysophospholipase I
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MET MET proto-oncogene, receptor tyrosine kinase
MOAP1 modulator of apoptosis 1
MPZL1 myelin protein zero-like 1
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NANS N-acetylneuraminic acid synthase
NFIB nuclear factor I/B
NMU neuromedin U
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
OXCT1 3-oxoacid CoA transferase 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBK PDZ binding kinase
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG10 paternally expressed 10
PHF20 PHD finger protein 20
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PKP2 plakophilin 2
PPA1 pyrophosphatase (inorganic) 1
PRKCI protein kinase C, iota
PRPF4 pre-mRNA processing factor 4
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
S100A13 S100 calcium binding protein A13
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SGCE sarcoglycan, epsilon
SGK1 serum/glucocorticoid regulated kinase 1
SLC16A6 solute carrier family 16, member 6
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMC2 structural maintenance of chromosomes 2
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBX3 T-box 3
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
THAP10 THAP domain containing 10
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
USP9Y ubiquitin specific peptidase 9, Y-linked
VTCN1 V-set domain containing T cell activation inhibitor 1
WBP5 WW domain binding protein 5
Funding