BRD-K00366212_2-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-8-methoxyquinazolin-4-amine KUC106573N_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

38 genes differentially expressed following the BRD-K00366212_2-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-8-methoxyquinazolin-4-amine KUC106573N_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASNS asparagine synthetase (glutamine-hydrolyzing)
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FCGBP Fc fragment of IgG binding protein
HSPA2 heat shock 70kDa protein 2
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
MT1E metallothionein 1E
MVP major vault protein
NEFL neurofilament, light polypeptide
RGS1 regulator of G-protein signaling 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLN sarcolipin
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ATF5 activating transcription factor 5
BGN biglycan
BIK BCL2-interacting killer (apoptosis-inducing)
CCND1 cyclin D1
CEMIP cell migration inducing protein, hyaluronan binding
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
FBLN1 fibulin 1
JAG1 jagged 1
MYB v-myb avian myeloblastosis viral oncogene homolog
NFIB nuclear factor I/B
NMI N-myc (and STAT) interactor
NNMT nicotinamide N-methyltransferase
NT5E 5'-nucleotidase, ecto (CD73)
RCAN1 regulator of calcineurin 1
SC5D sterol-C5-desaturase
SLC35F2 solute carrier family 35, member F2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TOB1 transducer of ERBB2, 1
Funding