BRD-K00627859_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-K00627859_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ADAM9 ADAM metallopeptidase domain 9
ADGRG2 adhesion G protein-coupled receptor G2
ALOX5 arachidonate 5-lipoxygenase
AQP1 aquaporin 1 (Colton blood group)
ARMCX3 armadillo repeat containing, X-linked 3
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
BLVRB biliverdin reductase B
C14ORF132 chromosome 14 open reading frame 132
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CALR calreticulin
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CORO1A coronin, actin binding protein, 1A
CPT1A carnitine palmitoyltransferase 1A (liver)
CRABP2 cellular retinoic acid binding protein 2
CXADR coxsackie virus and adenovirus receptor
CXCL8 chemokine (C-X-C motif) ligand 8
CYFIP2 cytoplasmic FMR1 interacting protein 2
DHDDS dehydrodolichyl diphosphate synthase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF5A eukaryotic translation initiation factor 5A
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F11R F11 receptor
FADS1 fatty acid desaturase 1
FAM134B family with sequence similarity 134, member B
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FKBP1A FK506 binding protein 1A, 12kDa
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GABARAPL1 GABA(A) receptor-associated protein like 1
GAL galanin/GMAP prepropeptide
GEM GTP binding protein overexpressed in skeletal muscle
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GSR glutathione reductase
HBB hemoglobin, beta
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI6 interferon, alpha-inducible protein 6
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0930 KIAA0930
LBH limb bud and heart development
MAP1B microtubule-associated protein 1B
MGST3 microsomal glutathione S-transferase 3
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
MSRB1 methionine sulfoxide reductase B1
MTA1 metastasis associated 1
MX1 MX dynamin-like GTPase 1
NCF2 neutrophil cytosolic factor 2
NPTX2 neuronal pentraxin II
NSFL1C NSFL1 (p97) cofactor (p47)
NTS neurotensin
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PID1 phosphotyrosine interaction domain containing 1
PLIN2 perilipin 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RGCC regulator of cell cycle
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN3 reticulon 3
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SELENBP1 selenium binding protein 1
SEPT6 septin 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPP1 secreted phosphoprotein 1
SRGN serglycin
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TUBA1A tubulin, alpha 1a
TUBA4A tubulin, alpha 4a
TUBB2B tubulin, beta 2B class IIb
TYROBP TYRO protein tyrosine kinase binding protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WBP5 WW domain binding protein 5

decreased expression

Symbol Name
AKAP8 A kinase (PRKA) anchor protein 8
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMOTL2 angiomotin like 2
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
CBFB core-binding factor, beta subunit
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCND1 cyclin D1
COL4A2 collagen, type IV, alpha 2
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DIO1 deiodinase, iodothyronine, type I
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EXOSC4 exosome component 4
FABP7 fatty acid binding protein 7, brain
FAM3C family with sequence similarity 3, member C
FAM57A family with sequence similarity 57, member A
FXYD3 FXYD domain containing ion transport regulator 3
GRWD1 glutamate-rich WD repeat containing 1
HMGA2 high mobility group AT-hook 2
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
KANK1 KN motif and ankyrin repeat domains 1
KLK10 kallikrein-related peptidase 10
KPNB1 karyopherin (importin) beta 1
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAMP5 lysosomal-associated membrane protein family, member 5
MET MET proto-oncogene, receptor tyrosine kinase
MOK MOK protein kinase
MSH6 mutS homolog 6
MYC v-myc avian myelocytomatosis viral oncogene homolog
NIP7 NIP7, nucleolar pre-rRNA processing protein
NR2F2 nuclear receptor subfamily 2, group F, member 2
OBSL1 obscurin-like 1
PBX3 pre-B-cell leukemia homeobox 3
PDLIM5 PDZ and LIM domain 5
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS1 regulator of G-protein signaling 1
RHOBTB3 Rho-related BTB domain containing 3
RPP25 ribonuclease P/MRP 25kDa subunit
SFRP1 secreted frizzled-related protein 1
SPTBN1 spectrin, beta, non-erythrocytic 1
TACSTD2 tumor-associated calcium signal transducer 2
TSEN2 TSEN2 tRNA splicing endonuclease subunit
XIST X inactive specific transcript (non-protein coding)
ZMYND11 zinc finger, MYND-type containing 11