BRD-K00627859_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

104 genes differentially expressed following the BRD-K00627859_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAK1 AP2 associated kinase 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ANXA5 annexin A5
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASMTL acetylserotonin O-methyltransferase-like
ASRGL1 asparaginase like 1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
B3GNT1
C14ORF132 chromosome 14 open reading frame 132
CCND3 cyclin D3
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDR2L cerebellar degeneration-related protein 2-like
CYFIP2 cytoplasmic FMR1 interacting protein 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYSL2 dihydropyrimidinase-like 2
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
FADS1 fatty acid desaturase 1
FAM134B family with sequence similarity 134, member B
FBLN5 fibulin 5
FN1 fibronectin 1
FOXO4 forkhead box O4
FXYD6 FXYD domain containing ion transport regulator 6
GABARAPL1 GABA(A) receptor-associated protein like 1
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GSTA4 glutathione S-transferase alpha 4
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPCAL1 hippocalcin-like 1
HSPA1A heat shock 70kDa protein 1A
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ILK integrin-linked kinase
LGALS1 lectin, galactoside-binding, soluble, 1
LPIN1 lipin 1
METRN meteorin, glial cell differentiation regulator
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MPZL1 myelin protein zero-like 1
OLFM1 olfactomedin 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM2 PDZ and LIM domain 2 (mystique)
PNMA2 paraneoplastic Ma antigen 2
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RABAC1 Rab acceptor 1 (prenylated)
RAP1GAP RAP1 GTPase activating protein
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SCPEP1 serine carboxypeptidase 1
SFTPC surfactant protein C
SFXN3 sideroflexin 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
STXBP1 syntaxin binding protein 1
SYNM synemin, intermediate filament protein
TNNT1 troponin T type 1 (skeletal, slow)
TSPAN4 tetraspanin 4
TUBA1A tubulin, alpha 1a
TUBA4A tubulin, alpha 4a
TWF2 twinfilin actin binding protein 2
VIM vimentin
WFS1 Wolfram syndrome 1 (wolframin)
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ADM adrenomedullin
ATF1 activating transcription factor 1
AUTS2 autism susceptibility candidate 2
CCNA2 cyclin A2
CDV3 CDV3 homolog (mouse)
COL15A1 collagen, type XV, alpha 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DENND2D DENN/MADD domain containing 2D
DKK1 dickkopf WNT signaling pathway inhibitor 1
EGR1 early growth response 1
EIF5 eukaryotic translation initiation factor 5
EREG epiregulin
FAM20B family with sequence similarity 20, member B
FST follistatin
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA2 GATA binding protein 2
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GPX2 glutathione peroxidase 2
KRT13 keratin 13, type I
LARP4B La ribonucleoprotein domain family, member 4B
LOC100505650 uncharacterized LOC100505650
LYZ lysozyme
MAN2A1 mannosidase, alpha, class 2A, member 1
MMP12 matrix metallopeptidase 12
NRP1 neuropilin 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
SENP6 SUMO1/sentrin specific peptidase 6
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCERG1 transcription elongation regulator 1
TDO2 tryptophan 2,3-dioxygenase
TUBB6 tubulin, beta 6 class V
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UMPS uridine monophosphate synthetase
WARS tryptophanyl-tRNA synthetase