BRD-K01436366_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

111 genes differentially expressed following the BRD-K01436366_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AREG amphiregulin
BCL6 B-cell CLL/lymphoma 6
BSG basigin (Ok blood group)
C4BPA complement component 4 binding protein, alpha
CCDC85B coiled-coil domain containing 85B
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CXCL11 chemokine (C-X-C motif) ligand 11
DCXR dicarbonyl/L-xylulose reductase
EPAS1 endothelial PAS domain protein 1
EZR ezrin
GJA1 gap junction protein, alpha 1, 43kDa
GPX2 glutathione peroxidase 2
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HN1 hematological and neurological expressed 1
IL1R1 interleukin 1 receptor, type I
INSIG1 insulin induced gene 1
KIAA0226L KIAA0226-like
KIAA1033 KIAA1033
LGALS4 lectin, galactoside-binding, soluble, 4
LPIN1 lipin 1
MALL mal, T-cell differentiation protein-like
MAN1A1 mannosidase, alpha, class 1A, member 1
MMD monocyte to macrophage differentiation-associated
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
MTUS1 microtubule associated tumor suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
NDNF neuron-derived neurotrophic factor
NOTCH1 notch 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PTPRO protein tyrosine phosphatase, receptor type, O
RGS13 regulator of G-protein signaling 13
RGS2 regulator of G-protein signaling 2
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SIK1 salt-inducible kinase 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A1 solute carrier family 38, member 1
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFRC transferrin receptor
TM4SF4 transmembrane 4 L six family member 4
TSPAN5 tetraspanin 5
TUBB2A tubulin, beta 2A class IIa
VCL vinculin
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB18 zinc finger and BTB domain containing 18
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADCY1 adenylate cyclase 1 (brain)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ASNS asparagine synthetase (glutamine-hydrolyzing)
BTN3A2 butyrophilin, subfamily 3, member A2
C2CD5 C2 calcium-dependent domain containing 5
CBR3 carbonyl reductase 3
CD96 CD96 molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CPVL carboxypeptidase, vitellogenic-like
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
DCLK1 doublecortin-like kinase 1
DEK DEK proto-oncogene
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
EFS embryonal Fyn-associated substrate
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM57A family with sequence similarity 57, member A
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GNAS GNAS complex locus
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HOMER3 homer scaffolding protein 3
HOXA10 homeobox A10
IFRD2 interferon-related developmental regulator 2
IGFBP3 insulin-like growth factor binding protein 3
JADE2 jade family PHD finger 2
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KEAP1 kelch-like ECH-associated protein 1
KRT18 keratin 18, type I
LY6E lymphocyte antigen 6 complex, locus E
MDK midkine (neurite growth-promoting factor 2)
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOK MOK protein kinase
MRPS2 mitochondrial ribosomal protein S2
NID1 nidogen 1
NRN1 neuritin 1
PDGFC platelet derived growth factor C
PLSCR3 phospholipid scramblase 3
PRC1 protein regulator of cytokinesis 1
PRDX2 peroxiredoxin 2
PRSS23 protease, serine, 23
SNX10 sorting nexin 10
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TPBG trophoblast glycoprotein
TRIP6 thyroid hormone receptor interactor 6
TYMS thymidylate synthetase
USP34 ubiquitin specific peptidase 34
VCAN versican