BRD-K01436366_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

146 genes differentially expressed following the BRD-K01436366_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDOB aldolase B, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ANKRD10 ankyrin repeat domain 10
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCDC92 coiled-coil domain containing 92
CCND2 cyclin D2
CHGB chromogranin B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLC Charcot-Leyden crystal galectin
COL11A1 collagen, type XI, alpha 1
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DEFA4 defensin, alpha 4, corticostatin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP5 dual specificity phosphatase 5
EPAS1 endothelial PAS domain protein 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FAM49A family with sequence similarity 49, member A
FGFR3 fibroblast growth factor receptor 3
FN1 fibronectin 1
FZD5 frizzled class receptor 5
GATA6 GATA binding protein 6
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GM2A GM2 ganglioside activator
GREM1 gremlin 1, DAN family BMP antagonist
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HLA-DRA major histocompatibility complex, class II, DR alpha
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IDI1 isopentenyl-diphosphate delta isomerase 1
IDO1 indoleamine 2,3-dioxygenase 1
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
ITGA6 integrin, alpha 6
JAG1 jagged 1
KCNK3 potassium channel, two pore domain subfamily K, member 3
LGALS4 lectin, galactoside-binding, soluble, 4
LGMN legumain
LIPG lipase, endothelial
LTBP1 latent transforming growth factor beta binding protein 1
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
MSMO1 methylsterol monooxygenase 1
MT1E metallothionein 1E
NCAM1 neural cell adhesion molecule 1
NDN necdin, melanoma antigen (MAGE) family member
NEB nebulin
NLRP2 NLR family, pyrin domain containing 2
NT5E 5'-nucleotidase, ecto (CD73)
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEG3 paternally expressed 3
PGK1 phosphoglycerate kinase 1
PID1 phosphotyrosine interaction domain containing 1
PRTN3 proteinase 3
PRUNE2 prune homolog 2 (Drosophila)
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
PTCH1 patched 1
RGS13 regulator of G-protein signaling 13
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SST somatostatin
STXBP1 syntaxin binding protein 1
SULF1 sulfatase 1
TBX3 T-box 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TMEM2 transmembrane protein 2
TPP1 tripeptidyl peptidase I
TSPAN12 tetraspanin 12
TXNIP thioredoxin interacting protein
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17

decreased expression

Symbol Name
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANXA11 annexin A11
ATF1 activating transcription factor 1
AURKA aurora kinase A
B3GNT1
CA12 carbonic anhydrase XII
CXCL8 chemokine (C-X-C motif) ligand 8
CYB561 cytochrome b561
EYA2 EYA transcriptional coactivator and phosphatase 2
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GNAS GNAS complex locus
GTF3A general transcription factor IIIA
HOXB7 homeobox B7
IGF1R insulin-like growth factor 1 receptor
KEAP1 kelch-like ECH-associated protein 1
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT19 keratin 19, type I
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTF lactotransferrin
MLPH melanophilin
MPPED2 metallophosphoesterase domain containing 2
MUC16 mucin 16, cell surface associated
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
N4BP2L2 NEDD4 binding protein 2-like 2
NFIB nuclear factor I/B
NME4 NME/NM23 nucleoside diphosphate kinase 4
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PARP2 poly (ADP-ribose) polymerase 2
PCOLCE procollagen C-endopeptidase enhancer
PLAC8 placenta-specific 8
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRR7 proline rich 7 (synaptic)
PTN pleiotrophin
RFX5 regulatory factor X, 5 (influences HLA class II expression)
SEPT9 septin 9
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SORBS3 sorbin and SH3 domain containing 3
SPDEF SAM pointed domain containing ETS transcription factor
TACSTD2 tumor-associated calcium signal transducer 2
TBX2 T-box 2
TCERG1 transcription elongation regulator 1
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TLE2 transducin-like enhancer of split 2
TM4SF1 transmembrane 4 L six family member 1
TOP2B topoisomerase (DNA) II beta 180kDa
TSKU tsukushi, small leucine rich proteoglycan
XBP1 X-box binding protein 1
Funding