BRD-K01436366_XMD-1150_HS578T_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

221 genes differentially expressed following the BRD-K01436366_XMD-1150_HS578T_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADA adenosine deaminase
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADI1 acireductone dioxygenase 1
AK4 adenylate kinase 4
AKAP8L A kinase (PRKA) anchor protein 8-like
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BSG basigin (Ok blood group)
BTG2 BTG family, member 2
CADM1 cell adhesion molecule 1
CCDC85B coiled-coil domain containing 85B
CCND1 cyclin D1
CD36 CD36 molecule (thrombospondin receptor)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CXCR4 chemokine (C-X-C motif) receptor 4
DBN1 drebrin 1
DMTF1 cyclin D binding myb-like transcription factor 1
DSP desmoplakin
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EXOSC4 exosome component 4
EZR ezrin
FABP4 fatty acid binding protein 4, adipocyte
FAM46A family with sequence similarity 46, member A
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FKBP1B FK506 binding protein 1B, 12.6 kDa
FTH1 ferritin, heavy polypeptide 1
FUCA1 fucosidase, alpha-L- 1, tissue
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATA6 GATA binding protein 6
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GPC4 glypican 4
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
H2BFS H2B histone family, member S (pseudogene)
HEBP1 heme binding protein 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HOMER1 homer scaffolding protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
ITGA6 integrin, alpha 6
ITGAV integrin, alpha V
JAG1 jagged 1
KIAA0513 KIAA0513
KLHL21 kelch-like family member 21
LAGE3 L antigen family, member 3
LAMA3 laminin, alpha 3
LMO3 LIM domain only 3 (rhombotin-like 2)
MIR22HG MIR22 host gene
MYO1B myosin IB
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PEG10 paternally expressed 10
PGK1 phosphoglycerate kinase 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLS1 plastin 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRR7 proline rich 7 (synaptic)
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RBP1 retinol binding protein 1, cellular
REEP1 receptor accessory protein 1
RPL31 ribosomal protein L31
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SOX9 SRY (sex determining region Y)-box 9
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPTSSA serine palmitoyltransferase, small subunit A
SQSTM1 sequestosome 1
SST somatostatin
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TKT transketolase
XK X-linked Kx blood group
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AEBP1 AE binding protein 1
AIM1 absent in melanoma 1
AKT3 v-akt murine thymoma viral oncogene homolog 3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP3 aquaporin 3 (Gill blood group)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BGN biglycan
BIRC3 baculoviral IAP repeat containing 3
CALML3 calmodulin-like 3
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CCNA2 cyclin A2
CCND2 cyclin D2
CDC25A cell division cycle 25A
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CNN1 calponin 1, basic, smooth muscle
COL1A1 collagen, type I, alpha 1
CREB3L1 cAMP responsive element binding protein 3-like 1
CRISP3 cysteine-rich secretory protein 3
CTGF connective tissue growth factor
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CYR61 cysteine-rich, angiogenic inducer, 61
DCK deoxycytidine kinase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EDN1 endothelin 1
EFS embryonal Fyn-associated substrate
EPHX3 epoxide hydrolase 3
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FOXM1 forkhead box M1
GATA3 GATA binding protein 3
GBP1 guanylate binding protein 1, interferon-inducible
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2
HOPX HOP homeobox
HOXB2 homeobox B2
HOXB6 homeobox B6
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDO1 indoleamine 2,3-dioxygenase 1
IFI16 interferon, gamma-inducible protein 16
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IL7R interleukin 7 receptor
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
KIF11 kinesin family member 11
KLF6 Kruppel-like factor 6
KRT13 keratin 13, type I
LMNB1 lamin B1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LY6D lymphocyte antigen 6 complex, locus D
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MSLN mesothelin
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NNMT nicotinamide N-methyltransferase
NOX4 NADPH oxidase 4
OLFML3 olfactomedin-like 3
PARP2 poly (ADP-ribose) polymerase 2
PDZD2 PDZ domain containing 2
PDZK1 PDZ domain containing 1
PLAT plasminogen activator, tissue
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKCH protein kinase C, eta
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RAI14 retinoic acid induced 14
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RFC3 replication factor C (activator 1) 3, 38kDa
RGS1 regulator of G-protein signaling 1
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SHCBP1 SHC SH2-domain binding protein 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRY2 sprouty homolog 2 (Drosophila)
SRSF6 serine/arginine-rich splicing factor 6
TACSTD2 tumor-associated calcium signal transducer 2
TARP TCR gamma alternate reading frame protein
TEX30 testis expressed 30
TFPI2 tissue factor pathway inhibitor 2
TGFB1I1 transforming growth factor beta 1 induced transcript 1
THBS1 thrombospondin 1
TMEM176B transmembrane protein 176B
TMEM97 transmembrane protein 97
TMPRSS11E transmembrane protease, serine 11E
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TP63 tumor protein p63
TRBC1 T cell receptor beta constant 1
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIM29 tripartite motif containing 29
TRIP13 thyroid hormone receptor interactor 13
TRIP6 thyroid hormone receptor interactor 6
UBE2C ubiquitin-conjugating enzyme E2C
UPK1A uroplakin 1A
VCAN versican
WARS tryptophanyl-tRNA synthetase
ZEB1 zinc finger E-box binding homeobox 1
ZWINT ZW10 interacting kinetochore protein
Funding