BRD-K01436366_XMD-1150_LNCAP_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

208 genes differentially expressed following the BRD-K01436366_XMD-1150_LNCAP_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ALDOC aldolase C, fructose-bisphosphate
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BASP1 brain abundant, membrane attached signal protein 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BPTF bromodomain PHD finger transcription factor
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CAPZB capping protein (actin filament) muscle Z-line, beta
CD47 CD47 molecule
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL4A5 collagen, type IV, alpha 5
CTSB cathepsin B
CTSH cathepsin H
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DMXL2 Dmx-like 2
ENO2 enolase 2 (gamma, neuronal)
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOLR1 folate receptor 1 (adult)
FUCA1 fucosidase, alpha-L- 1, tissue
GDE1 glycerophosphodiester phosphodiesterase 1
GLRX glutaredoxin (thioltransferase)
GPX1 glutathione peroxidase 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IRS1 insulin receptor substrate 1
JUN jun proto-oncogene
KTN1 kinectin 1 (kinesin receptor)
LAPTM4B lysosomal protein transmembrane 4 beta
LAPTM5 lysosomal protein transmembrane 5
LDOC1 leucine zipper, down-regulated in cancer 1
MAGED1 melanoma antigen family D1
MAN2B1 mannosidase, alpha, class 2B, member 1
MAP7 microtubule-associated protein 7
MET MET proto-oncogene, receptor tyrosine kinase
MKNK1 MAP kinase interacting serine/threonine kinase 1
MSRB2 methionine sulfoxide reductase B2
MTSS1 metastasis suppressor 1
MVP major vault protein
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NSG1 neuron specific gene family member 1
PEG10 paternally expressed 10
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLA2G15 phospholipase A2, group XV
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRAF2 PRA1 domain family, member 2
PRDX1 peroxiredoxin 1
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTN pleiotrophin
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
ROGDI rogdi homolog (Drosophila)
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC2 syndecan 2
SELENBP1 selenium binding protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SNX2 sorting nexin 2
SPTSSA serine palmitoyltransferase, small subunit A
STXBP1 syntaxin binding protein 1
TMEM2 transmembrane protein 2
TOX3 TOX high mobility group box family member 3
TPST2 tyrosylprotein sulfotransferase 2
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TXNIP thioredoxin interacting protein
VLDLR very low density lipoprotein receptor
WAC WW domain containing adaptor with coiled-coil

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ANO1 anoctamin 1, calcium activated chloride channel
ANXA1 annexin A1
ASPN asporin
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
BUB3 BUB3 mitotic checkpoint protein
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDT1 chromatin licensing and DNA replication factor 1
CENPU centromere protein U
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
COL10A1 collagen, type X, alpha 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CYCS cytochrome c, somatic
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DDB2 damage-specific DNA binding protein 2, 48kDa
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELOVL6 ELOVL fatty acid elongase 6
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM129A family with sequence similarity 129, member A
FANCI Fanconi anemia, complementation group I
FAS Fas cell surface death receptor
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GARS glycyl-tRNA synthetase
GATA3 GATA binding protein 3
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
HELLS helicase, lymphoid-specific
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HOXA10 homeobox A10
HOXC6 homeobox C6
IARS isoleucyl-tRNA synthetase
ICAM3 intercellular adhesion molecule 3
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF18B kinesin family member 18B
KIF23 kinesin family member 23
LMNB1 lamin B1
LOC81691 exonuclease NEF-sp
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAL mal, T-cell differentiation protein
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MKI67 marker of proliferation Ki-67
MPO myeloperoxidase
MSH2 mutS homolog 2
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NOLC1 nucleolar and coiled-body phosphoprotein 1
NPY1R neuropeptide Y receptor Y1
NR2F6 nuclear receptor subfamily 2, group F, member 6
PARP2 poly (ADP-ribose) polymerase 2
PLK1 polo-like kinase 1
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
PPIF peptidylprolyl isomerase F
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PROM1 prominin 1
PSAT1 phosphoserine aminotransferase 1
PTMA prothymosin, alpha
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RBBP8 retinoblastoma binding protein 8
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
SHCBP1 SHC SH2-domain binding protein 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A1 solute carrier family 38, member 1
SLC43A3 solute carrier family 43, member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMC2 structural maintenance of chromosomes 2
SORD sorbitol dehydrogenase
SPC25 SPC25, NDC80 kinetochore complex component
STC2 stanniocalcin 2
TMEM194A transmembrane protein 194A
TMEM97 transmembrane protein 97
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TWIST1 twist family bHLH transcription factor 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
UNG uracil-DNA glycosylase
VCAN versican
VRK1 vaccinia related kinase 1
XPOT exportin, tRNA
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
Funding