BRD-K01436366_XMD-1150_MDAMB231_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

285 genes differentially expressed following the BRD-K01436366_XMD-1150_MDAMB231_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADI1 acireductone dioxygenase 1
ALDOC aldolase C, fructose-bisphosphate
ASMTL acetylserotonin O-methyltransferase-like
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CCDC85B coiled-coil domain containing 85B
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFD complement factor D (adipsin)
CHMP4A charged multivesicular body protein 4A
CPM carboxypeptidase M
CTSH cathepsin H
CYB5A cytochrome b5 type A (microsomal)
DAPK1 death-associated protein kinase 1
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF3I eukaryotic translation initiation factor 3, subunit I
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EZR ezrin
FABP4 fatty acid binding protein 4, adipocyte
FADS3 fatty acid desaturase 3
FAM46A family with sequence similarity 46, member A
FAM50A family with sequence similarity 50, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FKBP14 FK506 binding protein 14, 22 kDa
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FYN FYN proto-oncogene, Src family tyrosine kinase
G6PD glucose-6-phosphate dehydrogenase
GDI1 GDP dissociation inhibitor 1
GLS glutaminase
GOLGA8B golgin A8 family, member B
GSTM3 glutathione S-transferase mu 3 (brain)
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
JAK1 Janus kinase 1
KAZN kazrin, periplakin interacting protein
KIF2C kinesin family member 2C
LAGE3 L antigen family, member 3
LAPTM4B lysosomal protein transmembrane 4 beta
LDLR low density lipoprotein receptor
LGMN legumain
LIMCH1 LIM and calponin homology domains 1
LPCAT1 lysophosphatidylcholine acyltransferase 1
LRRC16A leucine rich repeat containing 16A
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAGED1 melanoma antigen family D1
MAN1A1 mannosidase, alpha, class 1A, member 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MME membrane metallo-endopeptidase
MSMO1 methylsterol monooxygenase 1
MT1X metallothionein 1X
MYO5A myosin VA (heavy chain 12, myoxin)
MYRF myelin regulatory factor
NEU1 sialidase 1 (lysosomal sialidase)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NPIPB3 nuclear pore complex interacting protein family, member B3
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
OPN3 opsin 3
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PEG10 paternally expressed 10
PGK1 phosphoglycerate kinase 1
PGRMC2 progesterone receptor membrane component 2
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLK2 polo-like kinase 2
PNRC1 proline-rich nuclear receptor coactivator 1
R3HDM2 R3H domain containing 2
REG1A regenerating islet-derived 1 alpha
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RSRP1 arginine/serine-rich protein 1
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SECISBP2L SECIS binding protein 2-like
SESN1 sestrin 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPTSSA serine palmitoyltransferase, small subunit A
SQLE squalene epoxidase
SST somatostatin
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
STXBP1 syntaxin binding protein 1
TGFBR3 transforming growth factor, beta receptor III
TM7SF2 transmembrane 7 superfamily member 2
TMEM2 transmembrane protein 2
TPST2 tyrosylprotein sulfotransferase 2
TUBA1A tubulin, alpha 1a
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAT1 vesicle amine transport 1
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA1 annexin A1
APOA2 apolipoprotein A-II
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP3 aquaporin 3 (Gill blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
AURKB aurora kinase B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BIRC5 baculoviral IAP repeat containing 5
BMP2 bone morphogenetic protein 2
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1R complement component 1, r subcomponent
CALML5 calmodulin-like 5
CBR3 carbonyl reductase 3
CCL19 chemokine (C-C motif) ligand 19
CCL5 chemokine (C-C motif) ligand 5
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC5L cell division cycle 5-like
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDT1 chromatin licensing and DNA replication factor 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLU clusterin
COL4A2 collagen, type IV, alpha 2
COL6A2 collagen, type VI, alpha 2
CST1 cystatin SN
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
DBF4 DBF4 zinc finger
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DONSON downstream neighbor of SON
DPYSL3 dihydropyrimidinase-like 3
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FGL2 fibrinogen-like 2
FOXM1 forkhead box M1
FRZB frizzled-related protein
GAL galanin/GMAP prepropeptide
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPR171 G protein-coupled receptor 171
GUSB glucuronidase, beta
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HDGFRP3 hepatoma-derived growth factor, related protein 3
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HES1 hes family bHLH transcription factor 1
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOPX HOP homeobox
ICAM3 intercellular adhesion molecule 3
IDO1 indoleamine 2,3-dioxygenase 1
IFI16 interferon, gamma-inducible protein 16
IFRD2 interferon-related developmental regulator 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL17RB interleukin 17 receptor B
KANK1 KN motif and ankyrin repeat domains 1
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
LMNB1 lamin B1
LOXL1 lysyl oxidase-like 1
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MALL mal, T-cell differentiation protein-like
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NMI N-myc (and STAT) interactor
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUSAP1 nucleolar and spindle associated protein 1
PDHX pyruvate dehydrogenase complex, component X
PERP PERP, TP53 apoptosis effector
PKP1 plakophilin 1
PLBD1 phospholipase B domain containing 1
PLK1 polo-like kinase 1
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PTN pleiotrophin
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PTTG1 pituitary tumor-transforming 1
RAD51AP1 RAD51 associated protein 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBBP8 retinoblastoma binding protein 8
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RGS5 regulator of G-protein signaling 5
RPP25 ribonuclease P/MRP 25kDa subunit
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100P S100 calcium binding protein P
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SORBS2 sorbin and SH3 domain containing 2
SORBS3 sorbin and SH3 domain containing 3
SOX11 SRY (sex determining region Y)-box 11
SOX9 SRY (sex determining region Y)-box 9
SPATS2L spermatogenesis associated, serine-rich 2-like
SPRR1A small proline-rich protein 1A
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TF transferrin
TIPIN TIMELESS interacting protein
TM4SF1 transmembrane 4 L six family member 1
TMEM176B transmembrane protein 176B
TMPO thymopoietin
TNC tenascin C
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TPSAB1 tryptase alpha/beta 1
TPX2 TPX2, microtubule-associated
TRBC1 T cell receptor beta constant 1
TRIM14 tripartite motif containing 14
TRIM29 tripartite motif containing 29
UBE2C ubiquitin-conjugating enzyme E2C
USP1 ubiquitin specific peptidase 1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZEB1 zinc finger E-box binding homeobox 1
ZNF22 zinc finger protein 22
ZWINT ZW10 interacting kinetochore protein
Funding