BRD-K01436366_XMD-1150_MDAMB231_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

103 genes differentially expressed following the BRD-K01436366_XMD-1150_MDAMB231_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BLNK B-cell linker
C5 complement component 5
CASP3 caspase 3, apoptosis-related cysteine peptidase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHGB chromogranin B
CST6 cystatin E/M
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSTN destrin (actin depolymerizing factor)
EGR1 early growth response 1
FASN fatty acid synthase
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
GPNMB glycoprotein (transmembrane) nmb
GSN gelsolin
HES1 hes family bHLH transcription factor 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IGSF3 immunoglobulin superfamily, member 3
INSIG1 insulin induced gene 1
IRF8 interferon regulatory factor 8
MSMO1 methylsterol monooxygenase 1
MYO1B myosin IB
NDRG4 NDRG family member 4
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NOTCH1 notch 1
PLAGL1 pleiomorphic adenoma gene-like 1
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PRSS3 protease, serine, 3
PTPRE protein tyrosine phosphatase, receptor type, E
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
S100B S100 calcium binding protein B
SDC2 syndecan 2
SQLE squalene epoxidase
SRGN serglycin
STAT1 signal transducer and activator of transcription 1, 91kDa
STMN2 stathmin 2
TAC1 tachykinin, precursor 1
TMEM2 transmembrane protein 2
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TUBA1A tubulin, alpha 1a

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ANK2 ankyrin 2, neuronal
BHLHE41 basic helix-loop-helix family, member e41
BMP4 bone morphogenetic protein 4
BPHL biphenyl hydrolase-like (serine hydrolase)
CAPN2 calpain 2, (m/II) large subunit
CAST calpastatin
CD24 CD24 molecule
CKAP4 cytoskeleton-associated protein 4
CLU clusterin
CPVL carboxypeptidase, vitellogenic-like
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CXCL14 chemokine (C-X-C motif) ligand 14
DACH1 dachshund family transcription factor 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
EGFR epidermal growth factor receptor
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPHA3 EPH receptor A3
EVI2B ecotropic viral integration site 2B
FAM60A family with sequence similarity 60, member A
FOSL1 FOS-like antigen 1
FRZB frizzled-related protein
FST follistatin
GATA3 GATA binding protein 3
GLIPR1 GLI pathogenesis-related 1
GSAP gamma-secretase activating protein
GZMK granzyme K (granzyme 3; tryptase II)
HMGA2 high mobility group AT-hook 2
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
KDM5D lysine (K)-specific demethylase 5D
KRT19 keratin 19, type I
KYNU kynureninase
LTF lactotransferrin
MDK midkine (neurite growth-promoting factor 2)
NAV3 neuron navigator 3
NKX3-1 NK3 homeobox 1
PARP8 poly (ADP-ribose) polymerase family, member 8
PLEKHA5 pleckstrin homology domain containing, family A member 5
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
RAB38 RAB38, member RAS oncogene family
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SFRP1 secreted frizzled-related protein 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLIT2 slit homolog 2 (Drosophila)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPRY2 sprouty homolog 2 (Drosophila)
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TBX2 T-box 2
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TPR translocated promoter region, nuclear basket protein
TSPAN8 tetraspanin 8
ZBTB38 zinc finger and BTB domain containing 38
Funding