BRD-K01436366_XMD-1150_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

117 genes differentially expressed following the BRD-K01436366_XMD-1150_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ALDOC aldolase C, fructose-bisphosphate
AREG amphiregulin
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES1 carboxylesterase 1
CIRBP cold inducible RNA binding protein
CLDN10 claudin 10
COL4A5 collagen, type IV, alpha 5
CORO1C coronin, actin binding protein, 1C
CPA3 carboxypeptidase A3 (mast cell)
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
DAPK1 death-associated protein kinase 1
DMXL2 Dmx-like 2
DYNLT1 dynein, light chain, Tctex-type 1
FOLR1 folate receptor 1 (adult)
G6PD glucose-6-phosphate dehydrogenase
GNLY granulysin
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ILK integrin-linked kinase
JUN jun proto-oncogene
KLK5 kallikrein-related peptidase 5
LAGE3 L antigen family, member 3
LGALS1 lectin, galactoside-binding, soluble, 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MCOLN1 mucolipin 1
MYH10 myosin, heavy chain 10, non-muscle
NRGN neurogranin (protein kinase C substrate, RC3)
PF4 platelet factor 4
PRCP prolylcarboxypeptidase (angiotensinase C)
QKI QKI, KH domain containing, RNA binding
QPCT glutaminyl-peptide cyclotransferase
RHOB ras homolog family member B
RYBP RING1 and YY1 binding protein
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SNX2 sorting nexin 2
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRRM2 serine/arginine repetitive matrix 2
STK39 serine threonine kinase 39
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
THBS1 thrombospondin 1
TMEM45A transmembrane protein 45A
TSPAN13 tetraspanin 13
TSPAN3 tetraspanin 3
TUBB6 tubulin, beta 6 class V
VNN1 vanin 1

decreased expression

Symbol Name
ANXA1 annexin A1
APOD apolipoprotein D
AURKA aurora kinase A
BHLHE41 basic helix-loop-helix family, member e41
CCL2 chemokine (C-C motif) ligand 2
CCR2 chemokine (C-C motif) receptor 2
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COBL cordon-bleu WH2 repeat protein
COL15A1 collagen, type XV, alpha 1
COL1A2 collagen, type I, alpha 2
COLEC12 collectin sub-family member 12
CRABP1 cellular retinoic acid binding protein 1
DCN decorin
DENND2D DENN/MADD domain containing 2D
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FAM129A family with sequence similarity 129, member A
FBLN1 fibulin 1
FGL2 fibrinogen-like 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GPM6A glycoprotein M6A
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM3 intercellular adhesion molecule 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP6 insulin-like growth factor binding protein 6
IGL immunoglobulin lambda locus
IL1RN interleukin 1 receptor antagonist
IL7R interleukin 7 receptor
KRT13 keratin 13, type I
KRT15 keratin 15, type I
KRT18 keratin 18, type I
LAMP5 lysosomal-associated membrane protein family, member 5
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAL mal, T-cell differentiation protein
MGP matrix Gla protein
MT1M metallothionein 1M
MTA1 metastasis associated 1
NBL1 neuroblastoma 1, DAN family BMP antagonist
NEBL nebulette
NOV nephroblastoma overexpressed
NR2F1 nuclear receptor subfamily 2, group F, member 1
OPHN1 oligophrenin 1
PIP prolactin-induced protein
PITX1 paired-like homeodomain 1
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLAC8 placenta-specific 8
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PYCR1 pyrroline-5-carboxylate reductase 1
RELN reelin
RPP25 ribonuclease P/MRP 25kDa subunit
RRAGD Ras-related GTP binding D
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
STEAP1 six transmembrane epithelial antigen of the prostate 1
SYNM synemin, intermediate filament protein
TFF3 trefoil factor 3 (intestinal)
TGFB3 transforming growth factor, beta 3
THAP11 THAP domain containing 11
THBS4 thrombospondin 4
TM4SF1 transmembrane 4 L six family member 1
TSPAN8 tetraspanin 8
TYMS thymidylate synthetase
XBP1 X-box binding protein 1
Funding