BRD-K01614657_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

234 genes differentially expressed following the BRD-K01614657_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BCL3 B-cell CLL/lymphoma 3
BIRC3 baculoviral IAP repeat containing 3
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CARS cysteinyl-tRNA synthetase
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CREB3L2 cAMP responsive element binding protein 3-like 2
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GUSBP11 glucuronidase, beta pseudogene 11
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BI histone cluster 1, H2bi
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IGFBP3 insulin-like growth factor binding protein 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IL6 interleukin 6
INHBA inhibin, beta A
INHBB inhibin, beta B
INSIG1 insulin induced gene 1
IRF1 interferon regulatory factor 1
IRF7 interferon regulatory factor 7
IRF9 interferon regulatory factor 9
ISG20 interferon stimulated exonuclease gene 20kDa
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM6B lysine (K)-specific demethylase 6B
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
LOC100505650 uncharacterized LOC100505650
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MT1E metallothionein 1E
MT1G metallothionein 1G
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFIL3 nuclear factor, interleukin 3 regulated
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
PDGFA platelet-derived growth factor alpha polypeptide
PEG3 paternally expressed 3
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RND1 Rho family GTPase 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SELE selectin E
SIK1 salt-inducible kinase 1
SOCS3 suppressor of cytokine signaling 3
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
TFF3 trefoil factor 3 (intestinal)
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSC22D1 TSC22 domain family, member 1
TUFT1 tuftelin 1
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZBTB10 zinc finger and BTB domain containing 10
ZC3H12A zinc finger CCCH-type containing 12A
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF331 zinc finger protein 331
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADCY9 adenylate cyclase 9
ALOX5 arachidonate 5-lipoxygenase
ANPEP alanyl (membrane) aminopeptidase
ANXA4 annexin A4
APLP2 amyloid beta (A4) precursor-like protein 2
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
AURKA aurora kinase A
B3GNT1
CAV2 caveolin 2
CBX3 chromobox homolog 3
CCNA2 cyclin A2
CCNB1 cyclin B1
CCND1 cyclin D1
CCNF cyclin F
CCNG1 cyclin G1
CD93 CD93 molecule
CDCA4 cell division cycle associated 4
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
COL4A1 collagen, type IV, alpha 1
CRYZ crystallin, zeta (quinone reductase)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DOK4 docking protein 4
DPYSL2 dihydropyrimidinase-like 2
DYNLT3 dynein, light chain, Tctex-type 3
ERBB3 erb-b2 receptor tyrosine kinase 3
FLRT2 fibronectin leucine rich transmembrane protein 2
GDE1 glycerophosphodiester phosphodiesterase 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GNS glucosamine (N-acetyl)-6-sulfatase
GOLM1 golgi membrane protein 1
GTSE1 G-2 and S-phase expressed 1
HDAC1 histone deacetylase 1
HDGFRP3 hepatoma-derived growth factor, related protein 3
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HMGA2 high mobility group AT-hook 2
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HOXB7 homeobox B7
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
ICMT isoprenylcysteine carboxyl methyltransferase
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
LAPTM4B lysosomal protein transmembrane 4 beta
LBR lamin B receptor
MKI67 marker of proliferation Ki-67
MOB1A MOB kinase activator 1A
MPZL1 myelin protein zero-like 1
MXRA7 matrix-remodelling associated 7
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NEK2 NIMA-related kinase 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
PBK PDZ binding kinase
PGM1 phosphoglucomutase 1
PLK1 polo-like kinase 1
PODXL podocalyxin-like
PRSS23 protease, serine, 23
PSCA prostate stem cell antigen
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RBP1 retinol binding protein 1, cellular
RPS11 ribosomal protein S11
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SNX10 sorting nexin 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
STMN1 stathmin 1
TBC1D16 TBC1 domain family, member 16
TFDP1 transcription factor Dp-1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM9SF2 transmembrane 9 superfamily member 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM14 tripartite motif containing 14
TSPAN3 tetraspanin 3
TWF1 twinfilin actin binding protein 1
UBE2C ubiquitin-conjugating enzyme E2C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZMYM3 zinc finger, MYM-type 3