BRD-K01834163_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

102 genes differentially expressed following the BRD-K01834163_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD4 abhydrolase domain containing 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
APH1A APH1A gamma secretase subunit
AREG amphiregulin
ATP10B ATPase, class V, type 10B
CA12 carbonic anhydrase XII
CBR3 carbonyl reductase 3
CES1 carboxylesterase 1
COL15A1 collagen, type XV, alpha 1
COTL1 coactosin-like F-actin binding protein 1
CRNN cornulin
CTSZ cathepsin Z
DKK1 dickkopf WNT signaling pathway inhibitor 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP3 epithelial membrane protein 3
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GLA galactosidase, alpha
GPX2 glutathione peroxidase 2
GSTA4 glutathione S-transferase alpha 4
HMOX1 heme oxygenase 1
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGFBP6 insulin-like growth factor binding protein 6
IL6ST interleukin 6 signal transducer
JUN jun proto-oncogene
KYNU kynureninase
LPL lipoprotein lipase
MAP1B microtubule-associated protein 1B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NPR3 natriuretic peptide receptor 3
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
PBX1 pre-B-cell leukemia homeobox 1
PGD phosphogluconate dehydrogenase
PI3 peptidase inhibitor 3, skin-derived
PIR pirin (iron-binding nuclear protein)
PLAC8 placenta-specific 8
PPAP2B phosphatidic acid phosphatase type 2B
PRNP prion protein
RAP1GAP RAP1 GTPase activating protein
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRPX sushi-repeat containing protein, X-linked
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TKT transketolase
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican

decreased expression

Symbol Name
AMIGO2 adhesion molecule with Ig-like domain 2
AQP3 aquaporin 3 (Gill blood group)
C14ORF132 chromosome 14 open reading frame 132
CD59 CD59 molecule, complement regulatory protein
CFH complement factor H
GPNMB glycoprotein (transmembrane) nmb
HSPA8 heat shock 70kDa protein 8
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
ISG15 ISG15 ubiquitin-like modifier
KRT23 keratin 23, type I
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCALD neurocalcin delta
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRN1 neuritin 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PXDN peroxidasin
RGS13 regulator of G-protein signaling 13
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SDC2 syndecan 2
SELT selenoprotein T
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SFTPB surfactant protein B
SFTPC surfactant protein C
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC38A2 solute carrier family 38, member 2
SST somatostatin
TBX2 T-box 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
VAMP8 vesicle-associated membrane protein 8
Funding