BRD-K02113016_olaparib_HA1E_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-K02113016_olaparib_HA1E_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
BAX BCL2-associated X protein
C9ORF16 chromosome 9 open reading frame 16
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCK cholecystokinin
CCL19 chemokine (C-C motif) ligand 19
CCNA1 cyclin A1
CCND2 cyclin D2
CD52 CD52 molecule
CD9 CD9 molecule
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
CENPE centromere protein E, 312kDa
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLEC11A C-type lectin domain family 11, member A
CLIC3 chloride intracellular channel 3
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
CPA3 carboxypeptidase A3 (mast cell)
CRELD2 cysteine-rich with EGF-like domains 2
CSAD cysteine sulfinic acid decarboxylase
CSTA cystatin A (stefin A)
CTSZ cathepsin Z
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29
DPP4 dipeptidyl-peptidase 4
EMP1 epithelial membrane protein 1
FCHO1 FCH domain only 1
FLRT2 fibronectin leucine rich transmembrane protein 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HOPX HOP homeobox
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IRS1 insulin receptor substrate 1
LEF1 lymphoid enhancer-binding factor 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LTB lymphotoxin beta (TNF superfamily, member 3)
LYZ lysozyme
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MMP9 matrix metallopeptidase 9
MYOF myoferlin
NEB nebulin
PDLIM3 PDZ and LIM domain 3
PEG3 paternally expressed 3
PEX11A peroxisomal biogenesis factor 11 alpha
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
RAB11FIP1 RAB11 family interacting protein 1 (class I)
SDF2L1 stromal cell-derived factor 2-like 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SPON1 spondin 1, extracellular matrix protein
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TNNT1 troponin T type 1 (skeletal, slow)
TTN titin
USP6NL USP6 N-terminal like
VNN1 vanin 1
WDR7 WD repeat domain 7
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
ZNF83 zinc finger protein 83

decreased expression

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACAT1 acetyl-CoA acetyltransferase 1
ACTB actin, beta
ACTG2 actin, gamma 2, smooth muscle, enteric
AMD1 adenosylmethionine decarboxylase 1
ASCL1 achaete-scute family bHLH transcription factor 1
CADM1 cell adhesion molecule 1
CCL20 chemokine (C-C motif) ligand 20
CD46 CD46 molecule, complement regulatory protein
CRISP3 cysteine-rich secretory protein 3
CSRP2 cysteine and glycine-rich protein 2
CXCL12 chemokine (C-X-C motif) ligand 12
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSG2 desmoglein 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPHA3 EPH receptor A3
FAM107A family with sequence similarity 107, member A
FGFR1 fibroblast growth factor receptor 1
IGL immunoglobulin lambda locus
JAG1 jagged 1
KDM5D lysine (K)-specific demethylase 5D
KIF5C kinesin family member 5C
LEPR leptin receptor
MAP1B microtubule-associated protein 1B
MCAM melanoma cell adhesion molecule
MYH11 myosin, heavy chain 11, smooth muscle
MYLK myosin light chain kinase
ORC1 origin recognition complex, subunit 1
PAPOLA poly(A) polymerase alpha
PMEPA1 prostate transmembrane protein, androgen induced 1
PODXL podocalyxin-like
PROM1 prominin 1
QDPR quinoid dihydropteridine reductase
RNASET2 ribonuclease T2
RPS4Y1 ribosomal protein S4, Y-linked 1
SLC25A46 solute carrier family 25, member 46
SLC30A1 solute carrier family 30 (zinc transporter), member 1
STOM stomatin
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TP53 tumor protein p53
TUFT1 tuftelin 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
WDR61 WD repeat domain 61
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
Funding