Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
Category | transcriptomics |
Type | small molecule perturbation |
Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
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405 genes differentially expressed following the BRD-K02708799_GSK-1059615_MCF10A_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
Symbol | Name |
---|---|
1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 |
ACKR3 | atypical chemokine receptor 3 |
ADD3 | adducin 3 (gamma) |
AIM1 | absent in melanoma 1 |
AKR1C2 | aldo-keto reductase family 1, member C2 |
ALDH6A1 | aldehyde dehydrogenase 6 family, member A1 |
ANGPTL2 | angiopoietin-like 2 |
ANK3 | ankyrin 3, node of Ranvier (ankyrin G) |
ANKRD10 | ankyrin repeat domain 10 |
ANXA4 | annexin A4 |
APOD | apolipoprotein D |
AQP1 | aquaporin 1 (Colton blood group) |
AREG | amphiregulin |
ASPN | asporin |
BBS1 | Bardet-Biedl syndrome 1 |
BCL6 | B-cell CLL/lymphoma 6 |
BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like |
BTG1 | B-cell translocation gene 1, anti-proliferative |
C10ORF10 | chromosome 10 open reading frame 10 |
C14ORF132 | chromosome 14 open reading frame 132 |
C19ORF54 | chromosome 19 open reading frame 54 |
C1ORF54 | chromosome 1 open reading frame 54 |
C1RL | complement component 1, r subcomponent-like |
CALCOCO1 | calcium binding and coiled-coil domain 1 |
CAV1 | caveolin 1, caveolae protein, 22kDa |
CBLB | Cbl proto-oncogene B, E3 ubiquitin protein ligase |
CCNG2 | cyclin G2 |
CD59 | CD59 molecule, complement regulatory protein |
CD99 | CD99 molecule |
CDK19 | cyclin-dependent kinase 19 |
CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
CECR1 | cat eye syndrome chromosome region, candidate 1 |
CEP57 | centrosomal protein 57kDa |
CFB | complement factor B |
CFD | complement factor D (adipsin) |
CFLAR | CASP8 and FADD-like apoptosis regulator |
CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) |
CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 |
COL10A1 | collagen, type X, alpha 1 |
COL1A1 | collagen, type I, alpha 1 |
COL3A1 | collagen, type III, alpha 1 |
CST1 | cystatin SN |
CTBP2 | C-terminal binding protein 2 |
CTDSP2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 |
CTSK | cathepsin K |
CXCR4 | chemokine (C-X-C motif) receptor 4 |
CYBB | cytochrome b-245, beta polypeptide |
DCN | decorin |
DDAH2 | dimethylarginine dimethylaminohydrolase 2 |
DKK3 | dickkopf WNT signaling pathway inhibitor 3 |
DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 |
EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 |
EFEMP2 | EGF containing fibulin-like extracellular matrix protein 2 |
EFNA1 | ephrin-A1 |
EMP1 | epithelial membrane protein 1 |
EPHA3 | EPH receptor A3 |
EPS8 | epidermal growth factor receptor pathway substrate 8 |
ERBB2 | erb-b2 receptor tyrosine kinase 2 |
ERBB4 | erb-b2 receptor tyrosine kinase 4 |
FABP4 | fatty acid binding protein 4, adipocyte |
FADS3 | fatty acid desaturase 3 |
FAXDC2 | fatty acid hydroxylase domain containing 2 |
FBLN1 | fibulin 1 |
FBLN2 | fibulin 2 |
FBN1 | fibrillin 1 |
FEZ1 | fasciculation and elongation protein zeta 1 (zygin I) |
FHL1 | four and a half LIM domains 1 |
FOXO3 | forkhead box O3 |
FOXO4 | forkhead box O4 |
FTH1 | ferritin, heavy polypeptide 1 |
FZD7 | frizzled class receptor 7 |
GAA | glucosidase, alpha; acid |
GABARAPL1 | GABA(A) receptor-associated protein like 1 |
GAS6 | growth arrest-specific 6 |
GATA3 | GATA binding protein 3 |
GBP2 | guanylate binding protein 2, interferon-inducible |
GHR | growth hormone receptor |
GJA1 | gap junction protein, alpha 1, 43kDa |
GLUL | glutamate-ammonia ligase |
GPNMB | glycoprotein (transmembrane) nmb |
GPRC5B | G protein-coupled receptor, class C, group 5, member B |
GPX3 | glutathione peroxidase 3 |
GRN | granulin |
GSN | gelsolin |
GUSBP3 | glucuronidase, beta pseudogene 3 |
GYPC | glycophorin C (Gerbich blood group) |
HBP1 | HMG-box transcription factor 1 |
HDAC6 | histone deacetylase 6 |
HIST1H2AC | histone cluster 1, H2ac |
HIST1H2BD | histone cluster 1, H2bd |
HLA-E | major histocompatibility complex, class I, E |
HMOX1 | heme oxygenase 1 |
HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) |
IDS | iduronate 2-sulfatase |
IFITM1 | interferon induced transmembrane protein 1 |
IGBP1 | immunoglobulin (CD79A) binding protein 1 |
IL1R1 | interleukin 1 receptor, type I |
INSR | insulin receptor |
IPO13 | importin 13 |
IRF9 | interferon regulatory factor 9 |
ITGA10 | integrin, alpha 10 |
ITGAV | integrin, alpha V |
ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) |
JUP | junction plakoglobin |
KLF9 | Kruppel-like factor 9 |
KLHL24 | kelch-like family member 24 |
LAMP2 | lysosomal-associated membrane protein 2 |
LDOC1 | leucine zipper, down-regulated in cancer 1 |
LINC00341 | long intergenic non-protein coding RNA 341 |
LRRC1 | leucine rich repeat containing 1 |
LTBP1 | latent transforming growth factor beta binding protein 1 |
LXN | latexin |
MAGED2 | melanoma antigen family D2 |
MAOA | monoamine oxidase A |
MAP1B | microtubule-associated protein 1B |
MED13L | mediator complex subunit 13-like |
METTL7A | methyltransferase like 7A |
MME | membrane metallo-endopeptidase |
MMP7 | matrix metallopeptidase 7 |
MT1F | metallothionein 1F |
MXI1 | MAX interactor 1, dimerization protein |
MXRA5 | matrix-remodelling associated 5 |
MYO5C | myosin VC |
NARFL | nuclear prelamin A recognition factor-like |
NAV2 | neuron navigator 2 |
NDRG1 | N-myc downstream regulated 1 |
NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) |
NFE2L1 | nuclear factor, erythroid 2-like 1 |
NNMT | nicotinamide N-methyltransferase |
NOX4 | NADPH oxidase 4 |
NRN1 | neuritin 1 |
NUPR1 | nuclear protein, transcriptional regulator, 1 |
OPTN | optineurin |
ORAI3 | ORAI calcium release-activated calcium modulator 3 |
P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) |
PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 |
PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) |
PDGFD | platelet derived growth factor D |
PECAM1 | platelet/endothelial cell adhesion molecule 1 |
PEX11A | peroxisomal biogenesis factor 11 alpha |
PHF20 | PHD finger protein 20 |
PIK3IP1 | phosphoinositide-3-kinase interacting protein 1 |
PLA2G16 | phospholipase A2, group XVI |
PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) |
PLIN1 | perilipin 1 |
PLIN2 | perilipin 2 |
PLXNB2 | plexin B2 |
PNRC1 | proline-rich nuclear receptor coactivator 1 |
POLD4 | polymerase (DNA-directed), delta 4, accessory subunit |
PPAP2B | phosphatidic acid phosphatase type 2B |
PPL | periplakin |
PTK2 | protein tyrosine kinase 2 |
PXDN | peroxidasin |
PYCARD | PYD and CARD domain containing |
RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 |
RASGRP1 | RAS guanyl releasing protein 1 (calcium and DAG-regulated) |
RGCC | regulator of cell cycle |
RNASE4 | ribonuclease, RNase A family, 4 |
RNASET2 | ribonuclease T2 |
RRAS | related RAS viral (r-ras) oncogene homolog |
SAT1 | spermidine/spermine N1-acetyltransferase 1 |
SCPEP1 | serine carboxypeptidase 1 |
SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C |
SEPP1 | selenoprotein P, plasma, 1 |
SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 |
SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 |
SESN1 | sestrin 1 |
SFRP4 | secreted frizzled-related protein 4 |
SH3BGRL | SH3 domain binding glutamate-rich protein like |
SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 |
SLC35E2B | solute carrier family 35, member E2B |
SLC38A2 | solute carrier family 38, member 2 |
SLC7A7 | solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 |
SOX4 | SRY (sex determining region Y)-box 4 |
SPATA20 | spermatogenesis associated 20 |
SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 |
ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 |
ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 |
STK38L | serine/threonine kinase 38 like |
STON1 | stonin 1 |
SULF1 | sulfatase 1 |
SYNE2 | spectrin repeat containing, nuclear envelope 2 |
SYNPO | synaptopodin |
SYT17 | synaptotagmin XVII |
TBC1D16 | TBC1 domain family, member 16 |
TCEAL4 | transcription elongation factor A (SII)-like 4 |
TCF4 | transcription factor 4 |
TCFL5 | transcription factor-like 5 (basic helix-loop-helix) |
TFAP2A | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) |
TFPI2 | tissue factor pathway inhibitor 2 |
THBS2 | thrombospondin 2 |
TLE2 | transducin-like enhancer of split 2 |
TNS1 | tensin 1 |
TNS3 | tensin 3 |
TPP1 | tripeptidyl peptidase I |
TPSAB1 | tryptase alpha/beta 1 |
TPSB2 | tryptase beta 2 (gene/pseudogene) |
TRIM22 | tripartite motif containing 22 |
TSC22D3 | TSC22 domain family, member 3 |
TUBA1A | tubulin, alpha 1a |
TXNIP | thioredoxin interacting protein |
USP6NL | USP6 N-terminal like |
VAT1 | vesicle amine transport 1 |
VCAN | versican |
VTCN1 | V-set domain containing T cell activation inhibitor 1 |
WDR45 | WD repeat domain 45 |
WDTC1 | WD and tetratricopeptide repeats 1 |
WISP2 | WNT1 inducible signaling pathway protein 2 |
YPEL5 | yippee-like 5 (Drosophila) |
ZBTB16 | zinc finger and BTB domain containing 16 |
ZMYND8 | zinc finger, MYND-type containing 8 |
ZNF292 | zinc finger protein 292 |
ZNF423 | zinc finger protein 423 |
Symbol | Name |
---|---|
ABCE1 | ATP-binding cassette, sub-family E (OABP), member 1 |
ADRB2 | adrenoceptor beta 2, surface |
AK1 | adenylate kinase 1 |
ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 |
AMD1 | adenosylmethionine decarboxylase 1 |
ANXA3 | annexin A3 |
ARF4 | ADP-ribosylation factor 4 |
ARPC5L | actin related protein 2/3 complex, subunit 5-like |
ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide |
ATP5G1 | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) |
ATP5J2 | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2 |
BAG2 | BCL2-associated athanogene 2 |
BLMH | bleomycin hydrolase |
BOP1 | block of proliferation 1 |
C1QBP | complement component 1, q subcomponent binding protein |
CACYBP | calcyclin binding protein |
CCND1 | cyclin D1 |
CCT2 | chaperonin containing TCP1, subunit 2 (beta) |
CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) |
CD320 | CD320 molecule |
CDC20 | cell division cycle 20 |
CDC25A | cell division cycle 25A |
CDC6 | cell division cycle 6 |
CDK4 | cyclin-dependent kinase 4 |
CKS2 | CDC28 protein kinase regulatory subunit 2 |
COTL1 | coactosin-like F-actin binding protein 1 |
CSE1L | CSE1 chromosome segregation 1-like (yeast) |
CTPS1 | CTP synthase 1 |
CTSC | cathepsin C |
CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
CXCL8 | chemokine (C-X-C motif) ligand 8 |
CYCS | cytochrome c, somatic |
CYR61 | cysteine-rich, angiogenic inducer, 61 |
DBF4 | DBF4 zinc finger |
DDX39A | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A |
DLC1 | DLC1 Rho GTPase activating protein |
DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) |
DUSP6 | dual specificity phosphatase 6 |
EBP | emopamil binding protein (sterol isomerase) |
ECI2 | enoyl-CoA delta isomerase 2 |
EGR3 | early growth response 3 |
EIF2S1 | eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa |
EIF4E | eukaryotic translation initiation factor 4E |
EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 |
ELOVL6 | ELOVL fatty acid elongase 6 |
EMG1 | EMG1 N1-specific pseudouridine methyltransferase |
ENC1 | ectodermal-neural cortex 1 (with BTB domain) |
ENO1 | enolase 1, (alpha) |
EREG | epiregulin |
EXOSC2 | exosome component 2 |
EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit |
FABP5 | fatty acid binding protein 5 (psoriasis-associated) |
FAM216A | family with sequence similarity 216, member A |
FEN1 | flap structure-specific endonuclease 1 |
FGFBP1 | fibroblast growth factor binding protein 1 |
FJX1 | four jointed box 1 (Drosophila) |
FKBP11 | FK506 binding protein 11, 19 kDa |
FKBP14 | FK506 binding protein 14, 22 kDa |
FOSL1 | FOS-like antigen 1 |
GALE | UDP-galactose-4-epimerase |
GALNT3 | polypeptide N-acetylgalactosaminyltransferase 3 |
GCH1 | GTP cyclohydrolase 1 |
GINS1 | GINS complex subunit 1 (Psf1 homolog) |
GINS2 | GINS complex subunit 2 (Psf2 homolog) |
GLIPR1 | GLI pathogenesis-related 1 |
HBEGF | heparin-binding EGF-like growth factor |
HIST1H4C | histone cluster 1, H4c |
HNRNPAB | heterogeneous nuclear ribonucleoprotein A/B |
HPRT1 | hypoxanthine phosphoribosyltransferase 1 |
HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 |
HSPA1A | heat shock 70kDa protein 1A |
HSPA8 | heat shock 70kDa protein 8 |
HSPD1 | heat shock 60kDa protein 1 (chaperonin) |
HSPE1 | heat shock 10kDa protein 1 |
HSPH1 | heat shock 105kDa/110kDa protein 1 |
IFRD2 | interferon-related developmental regulator 2 |
IKBKAP | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein |
IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 |
INPP5A | inositol polyphosphate-5-phosphatase, 40kDa |
KIAA0020 | KIAA0020 |
KRT6B | keratin 6B, type II |
LAPTM4B | lysosomal protein transmembrane 4 beta |
LBR | lamin B receptor |
LCN2 | lipocalin 2 |
LRRC59 | leucine rich repeat containing 59 |
LSM4 | LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) |
LSM7 | LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) |
LTF | lactotransferrin |
MAK16 | MAK16 homolog (S. cerevisiae) |
MALL | mal, T-cell differentiation protein-like |
MAP2K3 | mitogen-activated protein kinase kinase 3 |
MCM10 | minichromosome maintenance complex component 10 |
MCM3 | minichromosome maintenance complex component 3 |
MCM4 | minichromosome maintenance complex component 4 |
MCM5 | minichromosome maintenance complex component 5 |
ME2 | malic enzyme 2, NAD(+)-dependent, mitochondrial |
MLEC | malectin |
MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 |
MMP9 | matrix metallopeptidase 9 |
MRPL12 | mitochondrial ribosomal protein L12 |
MRTO4 | mRNA turnover 4 homolog (S. cerevisiae) |
MUC5B | mucin 5B, oligomeric mucus/gel-forming |
MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 |
MYCBP | MYC binding protein |
NAV3 | neuron navigator 3 |
NME1 | NME/NM23 nucleoside diphosphate kinase 1 |
NOLC1 | nucleolar and coiled-body phosphoprotein 1 |
NOP16 | NOP16 nucleolar protein |
NOP56 | NOP56 ribonucleoprotein |
NUP98 | nucleoporin 98kDa |
NXT1 | nuclear transport factor 2-like export factor 1 |
ODC1 | ornithine decarboxylase 1 |
PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase |
PARP2 | poly (ADP-ribose) polymerase 2 |
PCNA | proliferating cell nuclear antigen |
PDSS1 | prenyl (decaprenyl) diphosphate synthase, subunit 1 |
PGC | progastricsin (pepsinogen C) |
PGM1 | phosphoglucomutase 1 |
PHB | prohibitin |
PHLDA1 | pleckstrin homology-like domain, family A, member 1 |
PHLDA2 | pleckstrin homology-like domain, family A, member 2 |
PI3 | peptidase inhibitor 3, skin-derived |
PLAC8 | placenta-specific 8 |
PNP | purine nucleoside phosphorylase |
POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit |
POLR3G | polymerase (RNA) III (DNA directed) polypeptide G (32kD) |
POLR3K | polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa |
POP5 | processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) |
PPIF | peptidylprolyl isomerase F |
PRPF19 | pre-mRNA processing factor 19 |
PRPS1 | phosphoribosyl pyrophosphate synthetase 1 |
PSME3 | proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) |
PSMG1 | proteasome (prosome, macropain) assembly chaperone 1 |
PUS7 | pseudouridylate synthase 7 (putative) |
QDPR | quinoid dihydropteridine reductase |
RANBP1 | RAN binding protein 1 |
RFC2 | replication factor C (activator 1) 2, 40kDa |
RFC3 | replication factor C (activator 1) 3, 38kDa |
RRM2 | ribonucleotide reductase M2 |
RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) |
RUVBL1 | RuvB-like AAA ATPase 1 |
S100A2 | S100 calcium binding protein A2 |
S100A9 | S100 calcium binding protein A9 |
S100P | S100 calcium binding protein P |
SCARB1 | scavenger receptor class B, member 1 |
SCGB2A1 | secretoglobin, family 2A, member 1 |
SCML1 | sex comb on midleg-like 1 (Drosophila) |
SDC1 | syndecan 1 |
SFN | stratifin |
SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase |
SLIRP | SRA stem-loop interacting RNA binding protein |
SLPI | secretory leukocyte peptidase inhibitor |
SNRPB | small nuclear ribonucleoprotein polypeptides B and B1 |
SNRPF | small nuclear ribonucleoprotein polypeptide F |
SPATS2L | spermatogenesis associated, serine-rich 2-like |
SRM | spermidine synthase |
SRPRB | signal recognition particle receptor, B subunit |
SRSF2 | serine/arginine-rich splicing factor 2 |
SRSF3 | serine/arginine-rich splicing factor 3 |
SRSF7 | serine/arginine-rich splicing factor 7 |
SSR1 | signal sequence receptor, alpha |
TESC | tescalcin |
TFF3 | trefoil factor 3 (intestinal) |
TFRC | transferrin receptor |
TGFA | transforming growth factor, alpha |
TIMM13 | translocase of inner mitochondrial membrane 13 homolog (yeast) |
TIMM8B | translocase of inner mitochondrial membrane 8 homolog B (yeast) |
TIPIN | TIMELESS interacting protein |
TMEM158 | transmembrane protein 158 (gene/pseudogene) |
TNC | tenascin C |
TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A |
TRAPPC3 | trafficking protein particle complex 3 |
TRIP13 | thyroid hormone receptor interactor 13 |
TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) |
TSPAN8 | tetraspanin 8 |
TUBB4B | tubulin, beta 4B class IVb |
TUBB6 | tubulin, beta 6 class V |
TXN | thioredoxin |
UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 |
UBE2N | ubiquitin-conjugating enzyme E2N |
UBE2S | ubiquitin-conjugating enzyme E2S |
UCHL3 | ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) |
UCHL5 | ubiquitin carboxyl-terminal hydrolase L5 |
UCK2 | uridine-cytidine kinase 2 |
USP1 | ubiquitin specific peptidase 1 |
VAPB | VAMP (vesicle-associated membrane protein)-associated protein B and C |
VRK1 | vaccinia related kinase 1 |
WDR12 | WD repeat domain 12 |
WNT5A | wingless-type MMTV integration site family, member 5A |
YRDC | yrdC N(6)-threonylcarbamoyltransferase domain containing |