BRD-K02708799_GSK-1059615_PC3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

170 genes differentially expressed following the BRD-K02708799_GSK-1059615_PC3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ANOS1 anosmin 1
AQP1 aquaporin 1 (Colton blood group)
ATP9A ATPase, class II, type 9A
BASP1 brain abundant, membrane attached signal protein 1
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
C3 complement component 3
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COL11A1 collagen, type XI, alpha 1
COLEC12 collectin sub-family member 12
CPM carboxypeptidase M
CTGF connective tissue growth factor
CXCL14 chemokine (C-X-C motif) ligand 14
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DMD dystrophin
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUOX2 dual oxidase 2
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
DYNLT3 dynein, light chain, Tctex-type 3
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM107A family with sequence similarity 107, member A
FBXO2 F-box protein 2
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXO1 forkhead box O1
GAB2 GRB2-associated binding protein 2
GATA6 GATA binding protein 6
GRN granulin
HDAC6 histone deacetylase 6
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
JAG1 jagged 1
JUND jun D proto-oncogene
KLF9 Kruppel-like factor 9
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LAMA4 laminin, alpha 4
LAPTM4B lysosomal protein transmembrane 4 beta
LEPR leptin receptor
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LIMCH1 LIM and calponin homology domains 1
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MARCKS myristoylated alanine-rich protein kinase C substrate
MMD monocyte to macrophage differentiation-associated
MT1F metallothionein 1F
MXRA5 matrix-remodelling associated 5
NEBL nebulette
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDLIM5 PDZ and LIM domain 5
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
POU2AF1 POU class 2 associating factor 1
PRSS23 protease, serine, 23
PTN pleiotrophin
PTRF polymerase I and transcript release factor
RANBP2 RAN binding protein 2
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS4 regulator of G-protein signaling 4
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SEPT2 septin 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SNAP25 synaptosomal-associated protein, 25kDa
SORBS2 sorbin and SH3 domain containing 2
SPARCL1 SPARC-like 1 (hevin)
SPEN spen family transcriptional repressor
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SYT1 synaptotagmin I
TAGLN transgelin
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TMEM255A transmembrane protein 255A
TMEM30B transmembrane protein 30B
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPBG trophoblast glycoprotein
TPP1 tripeptidyl peptidase I
TSPAN13 tetraspanin 13
TXNIP thioredoxin interacting protein
UBQLN2 ubiquilin 2
WDTC1 WD and tetratricopeptide repeats 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADD3 adducin 3 (gamma)
ALCAM activated leukocyte cell adhesion molecule
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANPEP alanyl (membrane) aminopeptidase
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA12 carbonic anhydrase XII
CCND2 cyclin D2
CD24 CD24 molecule
CGRRF1 cell growth regulator with ring finger domain 1
COTL1 coactosin-like F-actin binding protein 1
CREB1 cAMP responsive element binding protein 1
CRYAB crystallin, alpha B
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DPYSL2 dihydropyrimidinase-like 2
ECI2 enoyl-CoA delta isomerase 2
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
G0S2 G0/G1 switch 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPI glucose-6-phosphate isomerase
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HILPDA hypoxia inducible lipid droplet-associated
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
HOXC10 homeobox C10
HPRT1 hypoxanthine phosphoribosyltransferase 1
HTRA1 HtrA serine peptidase 1
KIAA0355 KIAA0355
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT15 keratin 15, type I
KRT23 keratin 23, type I
LDHB lactate dehydrogenase B
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MATN2 matrilin 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMO1 methylsterol monooxygenase 1
MYBPC1 myosin binding protein C, slow type
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PGK1 phosphoglycerate kinase 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
RPS5 ribosomal protein S5
S100A2 S100 calcium binding protein A2
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SLC38A1 solute carrier family 38, member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STK17A serine/threonine kinase 17a
TACSTD2 tumor-associated calcium signal transducer 2
TFF3 trefoil factor 3 (intestinal)
TMEM176B transmembrane protein 176B
TOP1 topoisomerase (DNA) I
Funding