BRD-K03063480_PF-477736_MCF10A_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

237 genes differentially expressed following the BRD-K03063480_PF-477736_MCF10A_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ALCAM activated leukocyte cell adhesion molecule
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BLVRB biliverdin reductase B
CARS cysteinyl-tRNA synthetase
CD44 CD44 molecule (Indian blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN10 claudin 10
COL21A1 collagen, type XXI, alpha 1
COL4A5 collagen, type IV, alpha 5
CSTA cystatin A (stefin A)
DDB2 damage-specific DNA binding protein 2, 48kDa
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSE dermatan sulfate epimerase
DUSP1 dual specificity phosphatase 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGR1 early growth response 1
EGR2 early growth response 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAXDC2 fatty acid hydroxylase domain containing 2
FDXR ferredoxin reductase
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXO4 forkhead box O4
GDF15 growth differentiation factor 15
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
GPC4 glypican 4
GPR137B G protein-coupled receptor 137B
GRB10 growth factor receptor-bound protein 10
GSTZ1 glutathione S-transferase zeta 1
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST3H2A histone cluster 3, H2a
IFITM2 interferon induced transmembrane protein 2
ISG20 interferon stimulated exonuclease gene 20kDa
KRT18 keratin 18, type I
KRT23 keratin 23, type I
KRT81 keratin 81, type II
KYNU kynureninase
LAMP2 lysosomal-associated membrane protein 2
LDOC1 leucine zipper, down-regulated in cancer 1
LRP10 low density lipoprotein receptor-related protein 10
LXN latexin
MAN2B1 mannosidase, alpha, class 2B, member 1
MAPT microtubule-associated protein tau
MME membrane metallo-endopeptidase
NMRK1 nicotinamide riboside kinase 1
NOTCH1 notch 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRBF2 nuclear receptor binding factor 2
NTS neurotensin
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
ORAI3 ORAI calcium release-activated calcium modulator 3
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDZK1IP1 PDZK1 interacting protein 1
PHGDH phosphoglycerate dehydrogenase
PLIN3 perilipin 3
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRAF2 PRA1 domain family, member 2
PSAT1 phosphoserine aminotransferase 1
RAB9A RAB9A, member RAS oncogene family
RGS2 regulator of G-protein signaling 2
RPS27L ribosomal protein S27-like
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100A11 S100 calcium binding protein A11
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC22A18 solute carrier family 22, member 18
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SPATA20 spermatogenesis associated 20
SRGN serglycin
STC2 stanniocalcin 2
STK38L serine/threonine kinase 38 like
SULF1 sulfatase 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
TIGAR TP53 induced glycolysis regulatory phosphatase
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPBG trophoblast glycoprotein
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
TST thiosulfate sulfurtransferase (rhodanese)
VCAN versican
WDR45 WD repeat domain 45
XBP1 X-box binding protein 1
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
AURKB aurora kinase B
BARD1 BRCA1 associated RING domain 1
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
CACYBP calcyclin binding protein
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CCNA2 cyclin A2
CCNE2 cyclin E2
CCNF cyclin F
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CENPA centromere protein A
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHD7 chromodomain helicase DNA binding protein 7
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DHFR dihydrofolate reductase
DONSON downstream neighbor of SON
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP7 fatty acid binding protein 7, brain
FANCG Fanconi anemia, complementation group G
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNAS GNAS complex locus
GPNMB glycoprotein (transmembrane) nmb
GTSE1 G-2 and S-phase expressed 1
HELLS helicase, lymphoid-specific
HIST1H2BG histone cluster 1, H2bg
HMGB2 high mobility group box 2
HSPA14 heat shock 70kDa protein 14
HSPA1A heat shock 70kDa protein 1A
HSPD1 heat shock 60kDa protein 1 (chaperonin)
INSM1 insulinoma-associated 1
ITGA6 integrin, alpha 6
ITGB1BP1 integrin beta 1 binding protein 1
KCTD12 potassium channel tetramerization domain containing 12
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LPL lipoprotein lipase
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MIS18A MIS18 kinetochore protein A
MMP12 matrix metallopeptidase 12
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NPY neuropeptide Y
NRG1 neuregulin 1
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PLK1 polo-like kinase 1
PMP22 peripheral myelin protein 22
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRMT1 protein arginine methyltransferase 1
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS5 regulator of G-protein signaling 5
RPIA ribose 5-phosphate isomerase A
RRM2 ribonucleotide reductase M2
SCG2 secretogranin II
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SMC4 structural maintenance of chromosomes 4
SNAP25 synaptosomal-associated protein, 25kDa
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SPP1 secreted phosphoprotein 1
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
STMN2 stathmin 2
SYCP2 synaptonemal complex protein 2
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TMEM194A transmembrane protein 194A
TMEM97 transmembrane protein 97
TMPO thymopoietin
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSPYL5 TSPY-like 5
UBE2S ubiquitin-conjugating enzyme E2S
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UNG uracil-DNA glycosylase
VRK1 vaccinia related kinase 1
WBP5 WW domain binding protein 5
WHSC1 Wolf-Hirschhorn syndrome candidate 1
ZNF22 zinc finger protein 22
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein
Funding