BRD-K03063480_PF-477736_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

114 genes differentially expressed following the BRD-K03063480_PF-477736_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADAMDEC1 ADAM-like, decysin 1
AGR2 anterior gradient 2
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BLVRB biliverdin reductase B
C3 complement component 3
C6ORF62 chromosome 6 open reading frame 62
C8ORF4 chromosome 8 open reading frame 4
CBS cystathionine-beta-synthase
CCL20 chemokine (C-C motif) ligand 20
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLIC5 chloride intracellular channel 5
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
DDIT4 DNA-damage-inducible transcript 4
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
FCGBP Fc fragment of IgG binding protein
FOXO1 forkhead box O1
GDF15 growth differentiation factor 15
GJA1 gap junction protein, alpha 1, 43kDa
GPRC5A G protein-coupled receptor, class C, group 5, member A
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IFITM1 interferon induced transmembrane protein 1
INHBB inhibin, beta B
ITGAV integrin, alpha V
KRT81 keratin 81, type II
MUC4 mucin 4, cell surface associated
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTS neurotensin
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAT1 phosphoserine aminotransferase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB9A RAB9A, member RAS oncogene family
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SIK1 salt-inducible kinase 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
TOB1 transducer of ERBB2, 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
USP6NL USP6 N-terminal like
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADRB2 adrenoceptor beta 2, surface
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CCNF cyclin F
CCP110 centriolar coiled coil protein 110kDa
CDC25A cell division cycle 25A
CIT citron rho-interacting serine/threonine kinase
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FAM46A family with sequence similarity 46, member A
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
KIF20A kinesin family member 20A
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LDHB lactate dehydrogenase B
MAOA monoamine oxidase A
MELK maternal embryonic leucine zipper kinase
MGLL monoglyceride lipase
NFIB nuclear factor I/B
PBK PDZ binding kinase
PBX3 pre-B-cell leukemia homeobox 3
PCOLCE2 procollagen C-endopeptidase enhancer 2
PROM1 prominin 1
REEP1 receptor accessory protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
SACS sacsin molecular chaperone
SFRP1 secreted frizzled-related protein 1
SLIT2 slit homolog 2 (Drosophila)
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNX10 sorting nexin 10
SRPX sushi-repeat containing protein, X-linked
TGM2 transglutaminase 2
TSPYL5 TSPY-like 5
TUBA1A tubulin, alpha 1a
VCAN versican
Funding