BRD-K03109492_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

98 genes differentially expressed following the BRD-K03109492_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BMP2 bone morphogenetic protein 2
C3ORF14 chromosome 3 open reading frame 14
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CTSK cathepsin K
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GLS glutaminase
GPNMB glycoprotein (transmembrane) nmb
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IL32 interleukin 32
INHBA inhibin, beta A
INPP1 inositol polyphosphate-1-phosphatase
INSIG1 insulin induced gene 1
JUND jun D proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KRT14 keratin 14, type I
KRT6A keratin 6A, type II
LDLR low density lipoprotein receptor
LRRC15 leucine rich repeat containing 15
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MMP3 matrix metallopeptidase 3
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NR4A1 nuclear receptor subfamily 4, group A, member 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLK2 polo-like kinase 2
RABGGTB Rab geranylgeranyltransferase, beta subunit
SCG2 secretogranin II
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase
UPP1 uridine phosphorylase 1
WISP2 WNT1 inducible signaling pathway protein 2
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
CCNF cyclin F
FAM171A1 family with sequence similarity 171, member A1
GANAB glucosidase, alpha; neutral AB
GATA2 GATA binding protein 2
GNAS GNAS complex locus
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITPKB inositol-trisphosphate 3-kinase B
JADE2 jade family PHD finger 2
LEF1 lymphoid enhancer-binding factor 1
LTBP3 latent transforming growth factor beta binding protein 3
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MGP matrix Gla protein
NRP1 neuropilin 1
PDZRN3 PDZ domain containing ring finger 3
PLK1 polo-like kinase 1
PROM1 prominin 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RHOBTB3 Rho-related BTB domain containing 3
RPS4Y1 ribosomal protein S4, Y-linked 1
SFRP1 secreted frizzled-related protein 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPTBN1 spectrin, beta, non-erythrocytic 1
SVIL supervillin
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D4 TBC1 domain family, member 4
TGFBR3 transforming growth factor, beta receptor III
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
Funding