BRD-K03406345_azacitidine_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

96 genes differentially expressed following the BRD-K03406345_azacitidine_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ARMCX1 armadillo repeat containing, X-linked 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BEX1 brain expressed, X-linked 1
BST2 bone marrow stromal cell antigen 2
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CD9 CD9 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CFB complement factor B
CTH cystathionine gamma-lyase
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
GADD45A growth arrest and DNA-damage-inducible, alpha
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MIR22HG MIR22 host gene
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NPIPB3 nuclear pore complex interacting protein family, member B3
NPR3 natriuretic peptide receptor 3
PCP4 Purkinje cell protein 4
PDGFA platelet-derived growth factor alpha polypeptide
PHGDH phosphoglycerate dehydrogenase
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PSAT1 phosphoserine aminotransferase 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
SARS seryl-tRNA synthetase
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SMYD3 SET and MYND domain containing 3
SQRDL sulfide quinone reductase-like (yeast)
SRGN serglycin
STAT1 signal transducer and activator of transcription 1, 91kDa
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AUTS2 autism susceptibility candidate 2
BACE2 beta-site APP-cleaving enzyme 2
BID BH3 interacting domain death agonist
CAV2 caveolin 2
CBR3 carbonyl reductase 3
CCNB1 cyclin B1
CCNF cyclin F
COPS7A COP9 signalosome subunit 7A
CSTA cystatin A (stefin A)
CX3CL1 chemokine (C-X3-C motif) ligand 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DEFB1 defensin, beta 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ENO1 enolase 1, (alpha)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPHA3 EPH receptor A3
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FKBP1A FK506 binding protein 1A, 12kDa
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GOLM1 golgi membrane protein 1
GRB14 growth factor receptor-bound protein 14
HMMR hyaluronan-mediated motility receptor (RHAMM)
KIF14 kinesin family member 14
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
MARCKSL1 MARCKS-like 1
NPDC1 neural proliferation, differentiation and control, 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCDH9 protocadherin 9
STK39 serine threonine kinase 39
TACSTD2 tumor-associated calcium signal transducer 2
TARP TCR gamma alternate reading frame protein
TOP2A topoisomerase (DNA) II alpha 170kDa
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIB2 tribbles pseudokinase 2
TSPAN8 tetraspanin 8
WWTR1 WW domain containing transcription regulator 1
Funding