BRD-K03449891_foretinib_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-K03449891_foretinib_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABHD4 abhydrolase domain containing 4
ACTN1 actinin, alpha 1
ADD3 adducin 3 (gamma)
AKR1C3 aldo-keto reductase family 1, member C3
AQP3 aquaporin 3 (Gill blood group)
AQP9 aquaporin 9
C10ORF10 chromosome 10 open reading frame 10
C1QB complement component 1, q subcomponent, B chain
CD59 CD59 molecule, complement regulatory protein
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DRAM1 DNA-damage regulated autophagy modulator 1
F5 coagulation factor V (proaccelerin, labile factor)
FAXDC2 fatty acid hydroxylase domain containing 2
FRMD4B FERM domain containing 4B
FYB FYN binding protein
GAB2 GRB2-associated binding protein 2
GPNMB glycoprotein (transmembrane) nmb
HIST1H2AC histone cluster 1, H2ac
IFI16 interferon, gamma-inducible protein 16
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL7R interleukin 7 receptor
INHBA inhibin, beta A
LAPTM5 lysosomal protein transmembrane 5
LBP lipopolysaccharide binding protein
LCN2 lipocalin 2
LEPROT leptin receptor overlapping transcript
LITAF lipopolysaccharide-induced TNF factor
LXN latexin
LYZ lysozyme
MTSS1 metastasis suppressor 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PRAME preferentially expressed antigen in melanoma
PXDN peroxidasin
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SRGN serglycin
STAB1 stabilin 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGM2 transglutaminase 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADM adrenomedullin
AMIGO2 adhesion molecule with Ig-like domain 2
AURKB aurora kinase B
BRCA1 breast cancer 1, early onset
CADM1 cell adhesion molecule 1
CCNA2 cyclin A2
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CXCL14 chemokine (C-X-C motif) ligand 14
EGR3 early growth response 3
F3 coagulation factor III (thromboplastin, tissue factor)
GAL galanin/GMAP prepropeptide
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
LGALS3 lectin, galactoside-binding, soluble, 3
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MYCBP MYC binding protein
NPTX1 neuronal pentraxin I
NPY neuropeptide Y
NR2F1 nuclear receptor subfamily 2, group F, member 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RBP1 retinol binding protein 1, cellular
S100A10 S100 calcium binding protein A10
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SFRP1 secreted frizzled-related protein 1
SPTSSA serine palmitoyltransferase, small subunit A
SRM spermidine synthase
SRSF7 serine/arginine-rich splicing factor 7
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAGLN transgelin
TFPI2 tissue factor pathway inhibitor 2
TNC tenascin C
TUBB4B tubulin, beta 4B class IVb
TYRP1 tyrosinase-related protein 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZWINT ZW10 interacting kinetochore protein
Funding