BRD-K03568209_7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c]azepin-1-one_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

94 genes differentially expressed following the BRD-K03568209_7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c]azepin-1-one_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA3 annexin A3
APP amyloid beta (A4) precursor protein
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCNE2 cyclin E2
CD200 CD200 molecule
CDC45 cell division cycle 45
CELF2 CUGBP, Elav-like family member 2
DNTT DNA nucleotidylexotransferase
DPYSL2 dihydropyrimidinase-like 2
FAM171A1 family with sequence similarity 171, member A1
FRZB frizzled-related protein
GUCY1B3 guanylate cyclase 1, soluble, beta 3
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HSPA8 heat shock 70kDa protein 8
IL17RB interleukin 17 receptor B
KLF4 Kruppel-like factor 4 (gut)
MRPS16 mitochondrial ribosomal protein S16
MT1M metallothionein 1M
MTSS1 metastasis suppressor 1
MUC16 mucin 16, cell surface associated
PAWR PRKC, apoptosis, WT1, regulator
PDE4DIP phosphodiesterase 4D interacting protein
PRR7 proline rich 7 (synaptic)
PXMP2 peroxisomal membrane protein 2, 22kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM251 transmembrane protein 251
TMSB15A thymosin beta 15a
TSPYL5 TSPY-like 5
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WDR61 WD repeat domain 61
ZNF32 zinc finger protein 32

decreased expression

Symbol Name
ADGRG1 adhesion G protein-coupled receptor G1
ADGRG2 adhesion G protein-coupled receptor G2
AKAP13 A kinase (PRKA) anchor protein 13
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
COL4A1 collagen, type IV, alpha 1
COL4A5 collagen, type IV, alpha 5
COL5A2 collagen, type V, alpha 2
CPD carboxypeptidase D
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
E2F2 E2F transcription factor 2
ERMP1 endoplasmic reticulum metallopeptidase 1
ETV1 ets variant 1
FKBP11 FK506 binding protein 11, 19 kDa
FNDC3B fibronectin type III domain containing 3B
GBP2 guanylate binding protein 2, interferon-inducible
GLRX glutaredoxin (thioltransferase)
GOLGA8A golgin A8 family, member A
GPI glucose-6-phosphate isomerase
GSN gelsolin
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
KRT18 keratin 18, type I
LAMA4 laminin, alpha 4
LAMB1 laminin, beta 1
LRP10 low density lipoprotein receptor-related protein 10
MIA melanoma inhibitory activity
MVP major vault protein
NBL1 neuroblastoma 1, DAN family BMP antagonist
NNMT nicotinamide N-methyltransferase
PDGFD platelet derived growth factor D
PRF1 perforin 1 (pore forming protein)
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCD protein kinase C, delta
RALGDS ral guanine nucleotide dissociation stimulator
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
REEP5 receptor accessory protein 5
S100A2 S100 calcium binding protein A2
SELENBP1 selenium binding protein 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SMAD3 SMAD family member 3
SPINK1 serine peptidase inhibitor, Kazal type 1
STX1A syntaxin 1A (brain)
TCF4 transcription factor 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TIMP3 TIMP metallopeptidase inhibitor 3
TRIB2 tribbles pseudokinase 2
TSPAN13 tetraspanin 13
WDTC1 WD and tetratricopeptide repeats 1