BRD-K03568209_7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c]azepin-1-one_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-K03568209_7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c]azepin-1-one_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ATF3 activating transcription factor 3
CERS6 ceramide synthase 6
CLDN4 claudin 4
COASY CoA synthase
CST3 cystatin C
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EMP1 epithelial membrane protein 1
GUCY1B3 guanylate cyclase 1, soluble, beta 3
H2BFS H2B histone family, member S (pseudogene)
HBD hemoglobin, delta
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HOMER2 homer scaffolding protein 2
HOPX HOP homeobox
KCTD5 potassium channel tetramerization domain containing 5
LGALS1 lectin, galactoside-binding, soluble, 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MYO6 myosin VI
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRGN neurogranin (protein kinase C substrate, RC3)
OSBPL1A oxysterol binding protein-like 1A
PDGFC platelet derived growth factor C
PRSS8 protease, serine, 8
PXMP2 peroxisomal membrane protein 2, 22kDa
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RCAN1 regulator of calcineurin 1
RGS10 regulator of G-protein signaling 10
RPS21 ribosomal protein S21
S100A9 S100 calcium binding protein A9
SCARB2 scavenger receptor class B, member 2
SH3BGR SH3 domain binding glutamate-rich protein
SPARCL1 SPARC-like 1 (hevin)
TCF4 transcription factor 4
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TM4SF1 transmembrane 4 L six family member 1
TOP1 topoisomerase (DNA) I
TSPAN1 tetraspanin 1

decreased expression

Symbol Name
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA1 annexin A1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AUTS2 autism susceptibility candidate 2
BTG1 B-cell translocation gene 1, anti-proliferative
CAV1 caveolin 1, caveolae protein, 22kDa
CES1 carboxylesterase 1
EDNRB endothelin receptor type B
ELN elastin
F11R F11 receptor
FBXL12 F-box and leucine-rich repeat protein 12
FGF9 fibroblast growth factor 9
FNDC3B fibronectin type III domain containing 3B
FXYD2 FXYD domain containing ion transport regulator 2
GOLGA8A golgin A8 family, member A
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GRK5 G protein-coupled receptor kinase 5
GSTA1 glutathione S-transferase alpha 1
IGFBP4 insulin-like growth factor binding protein 4
IQGAP1 IQ motif containing GTPase activating protein 1
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KRT7 keratin 7, type II
LAMB1 laminin, beta 1
LPP LIM domain containing preferred translocation partner in lipoma
LUM lumican
MAPT microtubule-associated protein tau
MYOF myoferlin
NDRG1 N-myc downstream regulated 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PIP prolactin-induced protein
PLIN2 perilipin 2
POU2AF1 POU class 2 associating factor 1
PTGIS prostaglandin I2 (prostacyclin) synthase
QPCT glutaminyl-peptide cyclotransferase
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RRAGD Ras-related GTP binding D
SDCBP syndecan binding protein (syntenin)
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SNX7 sorting nexin 7
SPTAN1 spectrin, alpha, non-erythrocytic 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TBX3 T-box 3
TNS1 tensin 1
TPD52L1 tumor protein D52-like 1
VAT1 vesicle amine transport 1
VCAN versican