BRD-K03568209_7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c]azepin-1-one_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

67 genes differentially expressed following the BRD-K03568209_7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c]azepin-1-one_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BGN biglycan
BHLHE41 basic helix-loop-helix family, member e41
BMP2 bone morphogenetic protein 2
CD9 CD9 molecule
CPE carboxypeptidase E
DOK5 docking protein 5
EPAS1 endothelial PAS domain protein 1
FAM107A family with sequence similarity 107, member A
FHL1 four and a half LIM domains 1
G0S2 G0/G1 switch 2
HTRA1 HtrA serine peptidase 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
MEF2C myocyte enhancer factor 2C
MMP1 matrix metallopeptidase 1
POSTN periostin, osteoblast specific factor
RGS5 regulator of G-protein signaling 5
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPL10 ribosomal protein L10
SPARCL1 SPARC-like 1 (hevin)
SULF1 sulfatase 1
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2

decreased expression

Symbol Name
AGR2 anterior gradient 2
AKAP7 A kinase (PRKA) anchor protein 7
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOD apolipoprotein D
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BASP1 brain abundant, membrane attached signal protein 1
BIK BCL2-interacting killer (apoptosis-inducing)
BST2 bone marrow stromal cell antigen 2
CHPT1 choline phosphotransferase 1
CLCN3 chloride channel, voltage-sensitive 3
CST3 cystatin C
DLD dihydrolipoamide dehydrogenase
FOXO4 forkhead box O4
FXYD3 FXYD domain containing ion transport regulator 3
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GLRX glutaredoxin (thioltransferase)
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GRHL2 grainyhead-like 2 (Drosophila)
HOXC6 homeobox C6
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
LAPTM4B lysosomal protein transmembrane 4 beta
MAPK6 mitogen-activated protein kinase 6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NKX3-1 NK3 homeobox 1
PLAC8 placenta-specific 8
PLS1 plastin 1
PRKCD protein kinase C, delta
RBM47 RNA binding motif protein 47
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC44A4 solute carrier family 44, member 4
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TMPRSS2 transmembrane protease, serine 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN13 tetraspanin 13