BRD-K03736784_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

153 genes differentially expressed following the BRD-K03736784_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AHI1 Abelson helper integration site 1
APOC1 apolipoprotein C-I
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARC activity-regulated cytoskeleton-associated protein
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BLNK B-cell linker
C1S complement component 1, s subcomponent
C5AR1 complement component 5a receptor 1
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CECR1 cat eye syndrome chromosome region, candidate 1
CFB complement factor B
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
COL1A1 collagen, type I, alpha 1
CTH cystathionine gamma-lyase
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNTT DNA nucleotidylexotransferase
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
EPAS1 endothelial PAS domain protein 1
ESR1 estrogen receptor 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXG1 forkhead box G1
GADD45A growth arrest and DNA-damage-inducible, alpha
GSE1 Gse1 coiled-coil protein
H2BFS H2B histone family, member S (pseudogene)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H2BK histone cluster 1, H2bk
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IFI30 interferon, gamma-inducible protein 30
IFITM1 interferon induced transmembrane protein 1
IFRD1 interferon-related developmental regulator 1
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KIAA0226L KIAA0226-like
KLF4 Kruppel-like factor 4 (gut)
KRT23 keratin 23, type I
LOC100505650 uncharacterized LOC100505650
LRIF1 ligand dependent nuclear receptor interacting factor 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MEG3 maternally expressed 3 (non-protein coding)
MEIS2 Meis homeobox 2
MFAP3L microfibrillar-associated protein 3-like
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MMP9 matrix metallopeptidase 9
MUC5B mucin 5B, oligomeric mucus/gel-forming
NCOA3 nuclear receptor coactivator 3
NELL2 NEL-like 2 (chicken)
ODC1 ornithine decarboxylase 1
PCF11 PCF11 cleavage and polyadenylation factor subunit
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKCB protein kinase C, beta
PSAT1 phosphoserine aminotransferase 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFN stratifin
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPON1 spondin 1, extracellular matrix protein
SRGN serglycin
TFPI2 tissue factor pathway inhibitor 2
TRIB3 tribbles pseudokinase 3
TSPAN7 tetraspanin 7
TXNL4B thioredoxin-like 4B
WIF1 WNT inhibitory factor 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACP6 acid phosphatase 6, lysophosphatidic
ANGPT1 angiopoietin 1
AREG amphiregulin
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASPH aspartate beta-hydroxylase
B3GNT1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BOP1 block of proliferation 1
BTBD3 BTB (POZ) domain containing 3
CCDC85B coiled-coil domain containing 85B
CCND1 cyclin D1
CD59 CD59 molecule, complement regulatory protein
CDC25B cell division cycle 25B
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUOX2 dual oxidase 2
DUSP4 dual specificity phosphatase 4
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
ERBB3 erb-b2 receptor tyrosine kinase 3
EXOSC4 exosome component 4
FEN1 flap structure-specific endonuclease 1
GSTM3 glutathione S-transferase mu 3 (brain)
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXB6 homeobox B6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGF1R insulin-like growth factor 1 receptor
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
ITGA6 integrin, alpha 6
KANK1 KN motif and ankyrin repeat domains 1
KDM5D lysine (K)-specific demethylase 5D
KHNYN KH and NYN domain containing
KLHL9 kelch-like family member 9
KRT14 keratin 14, type I
KRT18 keratin 18, type I
MBP myelin basic protein
MX2 MX dynamin-like GTPase 2
MYBPC1 myosin binding protein C, slow type
NAV2 neuron navigator 2
NPY neuropeptide Y
NRIP1 nuclear receptor interacting protein 1
PLIN2 perilipin 2
PRSS23 protease, serine, 23
PSRC1 proline/serine-rich coiled-coil 1
PUF60 poly-U binding splicing factor 60KDa
RPP25 ribonuclease P/MRP 25kDa subunit
RRAGA Ras-related GTP binding A
SCAND1 SCAN domain containing 1
SF1 splicing factor 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SORD sorbitol dehydrogenase
SPRY2 sprouty homolog 2 (Drosophila)
SYNM synemin, intermediate filament protein
TBC1D16 TBC1 domain family, member 16
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM185B transmembrane protein 185B
TMEM223 transmembrane protein 223
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNS3 tensin 3
TSPYL5 TSPY-like 5
Funding