BRD-K03816923_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-K03816923_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AREG amphiregulin
ATF3 activating transcription factor 3
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CFLAR CASP8 and FADD-like apoptosis regulator
CHIC2 cysteine-rich hydrophobic domain 2
CHN2 chimerin 2
COL10A1 collagen, type X, alpha 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DENND1B DENN/MADD domain containing 1B
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
EPAS1 endothelial PAS domain protein 1
F11R F11 receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXG1 forkhead box G1
FTH1 ferritin, heavy polypeptide 1
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GREM1 gremlin 1, DAN family BMP antagonist
HES1 hes family bHLH transcription factor 1
HIST1H2BG histone cluster 1, H2bg
HSPA1A heat shock 70kDa protein 1A
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IL1R1 interleukin 1 receptor, type I
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM6B lysine (K)-specific demethylase 6B
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KRT19 keratin 19, type I
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2A1 mannosidase, alpha, class 2A, member 1
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
METTL7A methyltransferase like 7A
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PER1 period circadian clock 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGS16 regulator of G-protein signaling 16
RGS17 regulator of G-protein signaling 17
RIPK2 receptor-interacting serine-threonine kinase 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLCO3A1 solute carrier organic anion transporter family, member 3A1
STC1 stanniocalcin 1
THBS2 thrombospondin 2
XIST X inactive specific transcript (non-protein coding)
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
C6ORF62 chromosome 6 open reading frame 62
CCNE1 cyclin E1
CCNF cyclin F
CD14 CD14 molecule
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CENPA centromere protein A
CETN2 centrin, EF-hand protein, 2
CHMP4A charged multivesicular body protein 4A
CKB creatine kinase, brain
CLU clusterin
CXCL5 chemokine (C-X-C motif) ligand 5
CYBB cytochrome b-245, beta polypeptide
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FAM178A family with sequence similarity 178, member A
FBXO9 F-box protein 9
GAS2 growth arrest-specific 2
GCH1 GTP cyclohydrolase 1
GIMAP4 GTPase, IMAP family member 4
GIMAP6 GTPase, IMAP family member 6
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPX1 glutathione peroxidase 1
HEXIM1 hexamethylene bis-acetamide inducible 1
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MSH6 mutS homolog 6
MTMR4 myotubularin related protein 4
NME4 NME/NM23 nucleoside diphosphate kinase 4
NUP62 nucleoporin 62kDa
PDZK1 PDZ domain containing 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLA1A phospholipase A1 member A
PLAC8 placenta-specific 8
PNMA1 paraneoplastic Ma antigen 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRKCA protein kinase C, alpha
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
RAD51C RAD51 paralog C
SAMM50 SAMM50 sorting and assembly machinery component
SCML1 sex comb on midleg-like 1 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF1 serine/arginine-rich splicing factor 1
SUB1 SUB1 homolog (S. cerevisiae)
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TLR4 toll-like receptor 4
TMEM14A transmembrane protein 14A
TMEM251 transmembrane protein 251
UBE3C ubiquitin protein ligase E3C
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
Funding