BRD-K04363266_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

148 genes differentially expressed following the BRD-K04363266_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACTL6A actin-like 6A
ADGRF5 adhesion G protein-coupled receptor F5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ANOS1 anosmin 1
AP2M1 adaptor-related protein complex 2, mu 1 subunit
AREG amphiregulin
ARMCX1 armadillo repeat containing, X-linked 1
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
BLVRB biliverdin reductase B
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CCND2 cyclin D2
CD163 CD163 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHMP4A charged multivesicular body protein 4A
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DENND2D DENN/MADD domain containing 2D
DIXDC1 DIX domain containing 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL2 dihydropyrimidinase-like 2
ECM1 extracellular matrix protein 1
EDNRA endothelin receptor type A
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV5 ets variant 5
FAM69A family with sequence similarity 69, member A
FILIP1L filamin A interacting protein 1-like
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
G0S2 G0/G1 switch 2
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPM6A glycoprotein M6A
GPM6B glycoprotein M6B
GSTZ1 glutathione S-transferase zeta 1
HBD hemoglobin, delta
HMGN5 high mobility group nucleosome binding domain 5
IDO1 indoleamine 2,3-dioxygenase 1
IER5 immediate early response 5
IGHM immunoglobulin heavy constant mu
IL13RA2 interleukin 13 receptor, alpha 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JCHAIN joining chain of multimeric IgA and IgM
LAMB3 laminin, beta 3
LMO3 LIM domain only 3 (rhombotin-like 2)
LRRC16A leucine rich repeat containing 16A
LUM lumican
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha)
MFSD10 major facilitator superfamily domain containing 10
MGLL monoglyceride lipase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MME membrane metallo-endopeptidase
MT1F metallothionein 1F
MZT2B mitotic spindle organizing protein 2B
NMU neuromedin U
NOTCH1 notch 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NTS neurotensin
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PDPN podoplanin
PDZD2 PDZ domain containing 2
PLK2 polo-like kinase 2
PLTP phospholipid transfer protein
POLR2H polymerase (RNA) II (DNA directed) polypeptide H
PPOX protoporphyrinogen oxidase
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PRKCI protein kinase C, iota
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PXDN peroxidasin
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
SELENBP1 selenium binding protein 1
SNAI2 snail family zinc finger 2
SSBP2 single-stranded DNA binding protein 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAB1 stabilin 1
SYBU syntabulin (syntaxin-interacting)
TFRC transferrin receptor
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TSC22D1 TSC22 domain family, member 1
TYROBP TYRO protein tyrosine kinase binding protein
VSIG4 V-set and immunoglobulin domain containing 4
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF160 zinc finger protein 160

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C2CD2 C2 calcium-dependent domain containing 2
CASP2 caspase 2, apoptosis-related cysteine peptidase
CD24 CD24 molecule
CHPT1 choline phosphotransferase 1
COL15A1 collagen, type XV, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
CYBA cytochrome b-245, alpha polypeptide
DEFB1 defensin, beta 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF4B eukaryotic translation initiation factor 4B
EMP3 epithelial membrane protein 3
F5 coagulation factor V (proaccelerin, labile factor)
FAM60A family with sequence similarity 60, member A
FLNB filamin B, beta
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
HOXC6 homeobox C6
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL1R2 interleukin 1 receptor, type II
IL1RN interleukin 1 receptor antagonist
KIF5C kinesin family member 5C
LTF lactotransferrin
LY75 lymphocyte antigen 75
LYST lysosomal trafficking regulator
MAPT microtubule-associated protein tau
MMP12 matrix metallopeptidase 12
NQO1 NAD(P)H dehydrogenase, quinone 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PEBP1 phosphatidylethanolamine binding protein 1
PGAM1 phosphoglycerate mutase 1 (brain)
PRAME preferentially expressed antigen in melanoma
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
S100A10 S100 calcium binding protein A10
S100A7 S100 calcium binding protein A7
SELL selectin L
SEPHS1 selenophosphate synthetase 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SORD sorbitol dehydrogenase
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGN serglycin
STAT1 signal transducer and activator of transcription 1, 91kDa
STC2 stanniocalcin 2
SVIL supervillin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
VAT1 vesicle amine transport 1
VIM vimentin
ZNF586 zinc finger protein 586
Funding