BRD-K04534322_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-K04534322_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
ATF6 activating transcription factor 6
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BTG1 B-cell translocation gene 1, anti-proliferative
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CCR7 chemokine (C-C motif) receptor 7
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CELF2 CUGBP, Elav-like family member 2
CGRRF1 cell growth regulator with ring finger domain 1
CHIC2 cysteine-rich hydrophobic domain 2
CLIC4 chloride intracellular channel 4
COPA coatomer protein complex, subunit alpha
CREM cAMP responsive element modulator
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EPRS glutamyl-prolyl-tRNA synthetase
FHL2 four and a half LIM domains 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GK glycerol kinase
GK3P glycerol kinase 3 pseudogene
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GRB10 growth factor receptor-bound protein 10
HAX1 HCLS1 associated protein X-1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
IFRD1 interferon-related developmental regulator 1
IGHD immunoglobulin heavy constant delta
INHBE inhibin, beta E
INSIG1 insulin induced gene 1
MARS methionyl-tRNA synthetase
MCL1 myeloid cell leukemia 1
MOCOS molybdenum cofactor sulfurase
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1X metallothionein 1X
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCF2 neutrophil cytosolic factor 2
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
PYCR1 pyrroline-5-carboxylate reductase 1
RNASE4 ribonuclease, RNase A family, 4
SARS seryl-tRNA synthetase
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TRIB3 tribbles pseudokinase 3
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ADGRL1 adhesion G protein-coupled receptor L1
ATF5 activating transcription factor 5
AURKA aurora kinase A
CADPS2 Ca++-dependent secretion activator 2
CCNE2 cyclin E2
CCNF cyclin F
COL5A2 collagen, type V, alpha 2
CTSO cathepsin O
CTSV cathepsin V
DKK1 dickkopf WNT signaling pathway inhibitor 1
FGFR2 fibroblast growth factor receptor 2
FZD7 frizzled class receptor 7
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GLIPR1 GLI pathogenesis-related 1
HOXC6 homeobox C6
KRT19 keratin 19, type I
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MYRF myelin regulatory factor
NID1 nidogen 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NRIP1 nuclear receptor interacting protein 1
PDZK1 PDZ domain containing 1
S100A10 S100 calcium binding protein A10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STAT1 signal transducer and activator of transcription 1, 91kDa
WNT5A wingless-type MMTV integration site family, member 5A