BRD-K04534322_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

48 genes differentially expressed following the BRD-K04534322_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AARS alanyl-tRNA synthetase
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ASNS asparagine synthetase (glutamine-hydrolyzing)
CARS cysteinyl-tRNA synthetase
CD24 CD24 molecule
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CLIC4 chloride intracellular channel 4
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FAM129A family with sequence similarity 129, member A
G6PD glucose-6-phosphate dehydrogenase
GCLM glutamate-cysteine ligase, modifier subunit
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IARS isoleucyl-tRNA synthetase
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
KRT19 keratin 19, type I
LINC00341 long intergenic non-protein coding RNA 341
LMO4 LIM domain only 4
MARS methionyl-tRNA synthetase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NSDHL NAD(P) dependent steroid dehydrogenase-like
PHGDH phosphoglycerate dehydrogenase
SARS seryl-tRNA synthetase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SQLE squalene epoxidase
STC2 stanniocalcin 2
SYBU syntabulin (syntaxin-interacting)
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
FGFR4 fibroblast growth factor receptor 4
GRB7 growth factor receptor-bound protein 7
MECOM MDS1 and EVI1 complex locus
ORC1 origin recognition complex, subunit 1
TFPI2 tissue factor pathway inhibitor 2
Funding