BRD-K04546108_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

127 genes differentially expressed following the BRD-K04546108_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AEBP1 AE binding protein 1
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
APOA1 apolipoprotein A-I
AREG amphiregulin
ARPP19 cAMP-regulated phosphoprotein, 19kDa
BHLHE41 basic helix-loop-helix family, member e41
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CGRRF1 cell growth regulator with ring finger domain 1
CKB creatine kinase, brain
COBLL1 cordon-bleu WH2 repeat protein-like 1
CPE carboxypeptidase E
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLK1 delta-like 1 homolog (Drosophila)
DPT dermatopontin
EGR3 early growth response 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FBLN1 fibulin 1
FCGBP Fc fragment of IgG binding protein
FHL1 four and a half LIM domains 1
G0S2 G0/G1 switch 2
GPC3 glypican 3
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HLF hepatic leukemia factor
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IL1RN interleukin 1 receptor antagonist
ITM2A integral membrane protein 2A
KDM5D lysine (K)-specific demethylase 5D
KLF6 Kruppel-like factor 6
KRT19 keratin 19, type I
KRT8 keratin 8, type II
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAOB monoamine oxidase B
MAP7 microtubule-associated protein 7
MXRA5 matrix-remodelling associated 5
OLFM1 olfactomedin 1
OLFM4 olfactomedin 4
OPHN1 oligophrenin 1
ORM1 orosomucoid 1
PENK proenkephalin
PLAGL1 pleiomorphic adenoma gene-like 1
PPAP2B phosphatidic acid phosphatase type 2B
PTGER4 prostaglandin E receptor 4 (subtype EP4)
REC8 REC8 meiotic recombination protein
RGS2 regulator of G-protein signaling 2
RNASET2 ribonuclease T2
SCG2 secretogranin II
SEPP1 selenoprotein P, plasma, 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SPINK1 serine peptidase inhibitor, Kazal type 1
SSPN sarcospan
SYBU syntabulin (syntaxin-interacting)
TATDN2 TatD DNase domain containing 2
THBS2 thrombospondin 2
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
ZFP36L2 ZFP36 ring finger protein-like 2
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AQP3 aquaporin 3 (Gill blood group)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
BRD8 bromodomain containing 8
CD58 CD58 molecule
CDC25B cell division cycle 25B
COL5A2 collagen, type V, alpha 2
CSRP2 cysteine and glycine-rich protein 2
CST1 cystatin SN
CTGF connective tissue growth factor
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
FOSL1 FOS-like antigen 1
FXYD5 FXYD domain containing ion transport regulator 5
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
H2AFY H2A histone family, member Y
IER3 immediate early response 3
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KLHDC10 kelch domain containing 10
KPNB1 karyopherin (importin) beta 1
LAMB1 laminin, beta 1
LBR lamin B receptor
LDHB lactate dehydrogenase B
LEF1 lymphoid enhancer-binding factor 1
MKI67 marker of proliferation Ki-67
NDC80 NDC80 kinetochore complex component
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NRN1 neuritin 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLK1 polo-like kinase 1
PODXL podocalyxin-like
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SMC4 structural maintenance of chromosomes 4
STX1A syntaxin 1A (brain)
THBS1 thrombospondin 1
TMEM2 transmembrane protein 2
TMEM5 transmembrane protein 5
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAPPC3 trafficking protein particle complex 3
TRIP6 thyroid hormone receptor interactor 6
TUBB6 tubulin, beta 6 class V
UBE2C ubiquitin-conjugating enzyme E2C
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
WNT5A wingless-type MMTV integration site family, member 5A
WWTR1 WW domain containing transcription regulator 1
XPO7 exportin 7
ZIC1 Zic family member 1
ZNF586 zinc finger protein 586
Funding