BRD-K04546108_JAK3 Inhibitor VI_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

362 genes differentially expressed following the BRD-K04546108_JAK3 Inhibitor VI_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADAM28 ADAM metallopeptidase domain 28
ADAMDEC1 ADAM-like, decysin 1
ADGRE5 adhesion G protein-coupled receptor E5
AHNAK2 AHNAK nucleoprotein 2
AIM2 absent in melanoma 2
APLP2 amyloid beta (A4) precursor-like protein 2
ARHGAP29 Rho GTPase activating protein 29
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARPP19 cAMP-regulated phosphoprotein, 19kDa
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCAM basal cell adhesion molecule (Lutheran blood group)
BCL2L1 BCL2-like 1
BCR breakpoint cluster region
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
C1ORF106 chromosome 1 open reading frame 106
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPG capping protein (actin filament), gelsolin-like
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL5 chemokine (C-C motif) ligand 5
CCND1 cyclin D1
CCND2 cyclin D2
CD14 CD14 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD9 CD9 molecule
CDC34 cell division cycle 34
COG7 component of oligomeric golgi complex 7
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
DCLK1 doublecortin-like kinase 1
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DFNA5 deafness, autosomal dominant 5
DHRS7 dehydrogenase/reductase (SDR family) member 7
DUSP6 dual specificity phosphatase 6
EIF5A eukaryotic translation initiation factor 5A
EPS8L1 EPS8-like 1
EREG epiregulin
F11R F11 receptor
FBP1 fructose-1,6-bisphosphatase 1
FHL1 four and a half LIM domains 1
FRMD4B FERM domain containing 4B
GAL galanin/GMAP prepropeptide
GCLC glutamate-cysteine ligase, catalytic subunit
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GSN gelsolin
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOPX HOP homeobox
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGKC immunoglobulin kappa constant
IL1RN interleukin 1 receptor antagonist
IL6R interleukin 6 receptor
INSM1 insulinoma-associated 1
IRF8 interferon regulatory factor 8
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JAG1 jagged 1
JUN jun proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
KDM5D lysine (K)-specific demethylase 5D
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LAPTM5 lysosomal protein transmembrane 5
LYZ lysozyme
MAOA monoamine oxidase A
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MRPS2 mitochondrial ribosomal protein S2
NCF2 neutrophil cytosolic factor 2
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NELL2 NEL-like 2 (chicken)
NOV nephroblastoma overexpressed
NPIPB3 nuclear pore complex interacting protein family, member B3
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
OLFM1 olfactomedin 1
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PERP PERP, TP53 apoptosis effector
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLBD1 phospholipase B domain containing 1
PLEK2 pleckstrin 2
PLTP phospholipid transfer protein
PPL periplakin
PRKD2 protein kinase D2
PRNP prion protein
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTHLH parathyroid hormone-like hormone
RAB14 RAB14, member RAS oncogene family
RAB38 RAB38, member RAS oncogene family
RGCC regulator of cell cycle
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFN stratifin
SLC43A3 solute carrier family 43, member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMAD1 SMAD family member 1
SOS1 son of sevenless homolog 1 (Drosophila)
SOWAHC sosondowah ankyrin repeat domain family member C
SPARCL1 SPARC-like 1 (hevin)
SPRR1B small proline-rich protein 1B
SPRY2 sprouty homolog 2 (Drosophila)
STAB1 stabilin 1
STX1A syntaxin 1A (brain)
STX3 syntaxin 3
TACSTD2 tumor-associated calcium signal transducer 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
VNN1 vanin 1
WDR47 WD repeat domain 47
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZEB1 zinc finger E-box binding homeobox 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACOT13 acyl-CoA thioesterase 13
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAM12 ADAM metallopeptidase domain 12
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMDHD2 amidohydrolase domain containing 2
APOLD1 apolipoprotein L domain containing 1
AQP3 aquaporin 3 (Gill blood group)
ASCC3 activating signal cointegrator 1 complex subunit 3
AURKA aurora kinase A
AURKB aurora kinase B
B9D1 B9 protein domain 1
BAG2 BCL2-associated athanogene 2
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BCCIP BRCA2 and CDKN1A interacting protein
BICC1 BicC family RNA binding protein 1
C6ORF120 chromosome 6 open reading frame 120
C6ORF48 chromosome 6 open reading frame 48
C6ORF62 chromosome 6 open reading frame 62
C9ORF3 chromosome 9 open reading frame 3
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CALR calreticulin
CALU calumenin
CAST calpastatin
CCNA2 cyclin A2
CDC25C cell division cycle 25C
CDCA3 cell division cycle associated 3
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN3 cyclin-dependent kinase inhibitor 3
CEMIP cell migration inducing protein, hyaluronan binding
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
CFI complement factor I
CHL1 cell adhesion molecule L1-like
CNN1 calponin 1, basic, smooth muscle
CNN2 calponin 2
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL18A1 collagen, type XVIII, alpha 1
COL1A1 collagen, type I, alpha 1
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
COMP cartilage oligomeric matrix protein
COX7B cytochrome c oxidase subunit VIIb
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYCS cytochrome c, somatic
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DACT1 dishevelled-binding antagonist of beta-catenin 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYSL3 dihydropyrimidinase-like 3
DZIP3 DAZ interacting zinc finger protein 3
EFCAB11 EF-hand calcium binding domain 11
EGF epidermal growth factor
EID1 EP300 interacting inhibitor of differentiation 1
EIF4B eukaryotic translation initiation factor 4B
EPHA3 EPH receptor A3
EPHB2 EPH receptor B2
EPN2 epsin 2
F3 coagulation factor III (thromboplastin, tissue factor)
FAM46A family with sequence similarity 46, member A
FAM64A family with sequence similarity 64, member A
FAP fibroblast activation protein, alpha
FBN1 fibrillin 1
FHL2 four and a half LIM domains 2
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
FN1 fibronectin 1
FOXF1 forkhead box F1
FZD6 frizzled class receptor 6
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GATA6 GATA binding protein 6
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GREB1 growth regulation by estrogen in breast cancer 1
GREM1 gremlin 1, DAN family BMP antagonist
GSTM3 glutathione S-transferase mu 3 (brain)
GSTP1 glutathione S-transferase pi 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
H2AFV H2A histone family, member V
HAS2 hyaluronan synthase 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
IL6ST interleukin 6 signal transducer
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ITGB5 integrin, beta 5
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KLK11 kallikrein-related peptidase 11
KRCC1 lysine-rich coiled-coil 1
LAPTM4B lysosomal protein transmembrane 4 beta
LEF1 lymphoid enhancer-binding factor 1
LMCD1 LIM and cysteine-rich domains 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LTBP1 latent transforming growth factor beta binding protein 1
LUM lumican
LXN latexin
MAGED1 melanoma antigen family D1
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MATN2 matrilin 2
MBNL2 muscleblind-like splicing regulator 2
MEIS3P1 Meis homeobox 3 pseudogene 1
MFAP3L microfibrillar-associated protein 3-like
MFSD10 major facilitator superfamily domain containing 10
MRPS33 mitochondrial ribosomal protein S33
MYH10 myosin, heavy chain 10, non-muscle
MYL9 myosin, light chain 9, regulatory
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
NEK2 NIMA-related kinase 2
NEK7 NIMA-related kinase 7
NEU1 sialidase 1 (lysosomal sialidase)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NQO1 NAD(P)H dehydrogenase, quinone 1
NREP neuronal regeneration related protein
NTS neurotensin
OLFM4 olfactomedin 4
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
OXTR oxytocin receptor
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBK PDZ binding kinase
PCM1 pericentriolar material 1
PCYOX1L prenylcysteine oxidase 1 like
PDGFD platelet derived growth factor D
PDLIM5 PDZ and LIM domain 5
PDZRN3 PDZ domain containing ring finger 3
PLCB4 phospholipase C, beta 4
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLK1 polo-like kinase 1
PLN phospholamban
PRAF2 PRA1 domain family, member 2
PRKD1 protein kinase D1
PRSS23 protease, serine, 23
PSIP1 PC4 and SFRS1 interacting protein 1
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTTG1 pituitary tumor-transforming 1
PYCR1 pyrroline-5-carboxylate reductase 1
QKI QKI, KH domain containing, RNA binding
QPRT quinolinate phosphoribosyltransferase
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPA3 replication protein A3, 14kDa
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RPS27L ribosomal protein S27-like
SCN3A sodium channel, voltage gated, type III alpha subunit
SDC2 syndecan 2
SEC11A SEC11 homolog A (S. cerevisiae)
SERINC5 serine incorporator 5
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMC4 structural maintenance of chromosomes 4
SMYD3 SET and MYND domain containing 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
SPINK1 serine peptidase inhibitor, Kazal type 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SULF1 sulfatase 1
SYNGR1 synaptogyrin 1
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TACC3 transforming, acidic coiled-coil containing protein 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM47 transmembrane protein 47
TNC tenascin C
TOX3 TOX high mobility group box family member 3
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TRAK2 trafficking protein, kinesin binding 2
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TSPAN8 tetraspanin 8
TUBB6 tubulin, beta 6 class V
UBE2C ubiquitin-conjugating enzyme E2C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UQCRB ubiquinol-cytochrome c reductase binding protein
VCAN versican
WDR61 WD repeat domain 61
WNT5A wingless-type MMTV integration site family, member 5A
Funding