BRD-K04546108_JAK3 Inhibitor VI_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

345 genes differentially expressed following the BRD-K04546108_JAK3 Inhibitor VI_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AQP1 aquaporin 1 (Colton blood group)
ARHGAP29 Rho GTPase activating protein 29
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BIRC3 baculoviral IAP repeat containing 3
BLNK B-cell linker
BMP2 bone morphogenetic protein 2
BTG3 BTG family, member 3
C18ORF8 chromosome 18 open reading frame 8
CASP7 caspase 7, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CD36 CD36 molecule (thrombospondin receptor)
CD9 CD9 molecule
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CES1 carboxylesterase 1
CLDN1 claudin 1
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTSE cathepsin E
DHRS7 dehydrogenase/reductase (SDR family) member 7
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
DUSP5 dual specificity phosphatase 5
DUSP8 dual specificity phosphatase 8
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
EMP3 epithelial membrane protein 3
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FLNA filamin A, alpha
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GAB2 GRB2-associated binding protein 2
GCH1 GTP cyclohydrolase 1
GPR183 G protein-coupled receptor 183
GPX3 glutathione peroxidase 3
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HDAC9 histone deacetylase 9
HIST1H1C histone cluster 1, H1c
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
ICAM1 intercellular adhesion molecule 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI6 interferon, alpha-inducible protein 6
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
IL10RA interleukin 10 receptor, alpha
IL13RA2 interleukin 13 receptor, alpha 2
IRF7 interferon regulatory factor 7
JUN jun proto-oncogene
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KLK10 kallikrein-related peptidase 10
KLK5 kallikrein-related peptidase 5
KLK7 kallikrein-related peptidase 7
KLK8 kallikrein-related peptidase 8
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT19 keratin 19, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
MEOX2 mesenchyme homeobox 2
MGLL monoglyceride lipase
MICB MHC class I polypeptide-related sequence B
MOK MOK protein kinase
MTERF3 mitochondrial transcription termination factor 3
NCF2 neutrophil cytosolic factor 2
NEFL neurofilament, light polypeptide
NR1H2 nuclear receptor subfamily 1, group H, member 2
NUPL1 nucleoporin like 1
OSER1 oxidative stress responsive serine-rich 1
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
PEA15 phosphoprotein enriched in astrocytes 15
PELI1 pellino E3 ubiquitin protein ligase 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PLA2G15 phospholipase A2, group XV
PLIN2 perilipin 2
PLTP phospholipid transfer protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRNP prion protein
PRPF4 pre-mRNA processing factor 4
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTHLH parathyroid hormone-like hormone
PTRF polymerase I and transcript release factor
RAI2 retinoic acid induced 2
RBP1 retinol binding protein 1, cellular
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RHOA ras homolog family member A
RHOB ras homolog family member B
SDC4 syndecan 4
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SLC43A3 solute carrier family 43, member 3
SMIM7 small integral membrane protein 7
SYBU syntabulin (syntaxin-interacting)
TICAM1 toll-like receptor adaptor molecule 1
TJP2 tight junction protein 2
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
TUBB6 tubulin, beta 6 class V
UGCG UDP-glucose ceramide glucosyltransferase
UPP1 uridine phosphorylase 1
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WDR47 WD repeat domain 47
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF410 zinc finger protein 410
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACOT13 acyl-CoA thioesterase 13
ACP6 acid phosphatase 6, lysophosphatidic
ACTG2 actin, gamma 2, smooth muscle, enteric
AGR2 anterior gradient 2
AMDHD2 amidohydrolase domain containing 2
AQP3 aquaporin 3 (Gill blood group)
ASCC3 activating signal cointegrator 1 complex subunit 3
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASRGL1 asparaginase like 1
AURKA aurora kinase A
B3GNT1
B9D1 B9 protein domain 1
BAG1 BCL2-associated athanogene
BASP1 brain abundant, membrane attached signal protein 1
BICC1 BicC family RNA binding protein 1
BIK BCL2-interacting killer (apoptosis-inducing)
BIRC5 baculoviral IAP repeat containing 5
BPHL biphenyl hydrolase-like (serine hydrolase)
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C16ORF45 chromosome 16 open reading frame 45
C4ORF27 chromosome 4 open reading frame 27
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CALR calreticulin
CALU calumenin
CAST calpastatin
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDC5L cell division cycle 5-like
CDCA3 cell division cycle associated 3
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CFI complement factor I
CHL1 cell adhesion molecule L1-like
CHN2 chimerin 2
CIRBP cold inducible RNA binding protein
CIT citron rho-interacting serine/threonine kinase
COL18A1 collagen, type XVIII, alpha 1
CP ceruloplasmin (ferroxidase)
CPD carboxypeptidase D
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYBA cytochrome b-245, alpha polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNM1 dynamin 1
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DST dystonin
DZIP3 DAZ interacting zinc finger protein 3
ECI2 enoyl-CoA delta isomerase 2
EFCAB11 EF-hand calcium binding domain 11
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EIF4B eukaryotic translation initiation factor 4B
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPHB2 EPH receptor B2
EPN2 epsin 2
ETV1 ets variant 1
FAM64A family with sequence similarity 64, member A
FBN1 fibrillin 1
FBXO9 F-box protein 9
FGA fibrinogen alpha chain
FGF13 fibroblast growth factor 13
FGFR3 fibroblast growth factor receptor 3
GALE UDP-galactose-4-epimerase
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GMDS GDP-mannose 4,6-dehydratase
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRB14 growth factor receptor-bound protein 14
GSTA4 glutathione S-transferase alpha 4
GTSE1 G-2 and S-phase expressed 1
HADH hydroxyacyl-CoA dehydrogenase
HES1 hes family bHLH transcription factor 1
HMGB3 high mobility group box 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNMT histamine N-methyltransferase
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IRS1 insulin receptor substrate 1
ITGB5 integrin, beta 5
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JADE2 jade family PHD finger 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD3 potassium channel tetramerization domain containing 3
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
LAMB1 laminin, beta 1
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LIMCH1 LIM and calponin homology domains 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LOXL2 lysyl oxidase-like 2
LUM lumican
LXN latexin
MAP2K6 mitogen-activated protein kinase kinase 6
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MARCKSL1 MARCKS-like 1
MEIS3P1 Meis homeobox 3 pseudogene 1
MKI67 marker of proliferation Ki-67
MNS1 meiosis-specific nuclear structural 1
MRPL40 mitochondrial ribosomal protein L40
MRPS16 mitochondrial ribosomal protein S16
MRPS33 mitochondrial ribosomal protein S33
MUC1 mucin 1, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
NCK2 NCK adaptor protein 2
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
NEK2 NIMA-related kinase 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NID2 nidogen 2 (osteonidogen)
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NQO1 NAD(P)H dehydrogenase, quinone 1
NTS neurotensin
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
OLFM4 olfactomedin 4
OPHN1 oligophrenin 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PAAF1 proteasomal ATPase-associated factor 1
PBK PDZ binding kinase
PCDH9 protocadherin 9
PCSK1 proprotein convertase subtilisin/kexin type 1
PDGFD platelet derived growth factor D
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDZRN3 PDZ domain containing ring finger 3
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLK1 polo-like kinase 1
PPA2 pyrophosphatase (inorganic) 2
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRC1 protein regulator of cytokinesis 1
PSD3 pleckstrin and Sec7 domain containing 3
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGES prostaglandin E synthase
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTPRD protein tyrosine phosphatase, receptor type, D
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PTTG1 pituitary tumor-transforming 1
PYCR1 pyrroline-5-carboxylate reductase 1
QPRT quinolinate phosphoribosyltransferase
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RHOBTB3 Rho-related BTB domain containing 3
RNASE4 ribonuclease, RNase A family, 4
RPS11 ribosomal protein S11
RPS27L ribosomal protein S27-like
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SCARB1 scavenger receptor class B, member 1
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SFRP1 secreted frizzled-related protein 1
SH3YL1 SH3 and SYLF domain containing 1
SIM2 single-minded family bHLH transcription factor 2
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMC4 structural maintenance of chromosomes 4
SORD sorbitol dehydrogenase
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPP1 secreted phosphoprotein 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TACC3 transforming, acidic coiled-coil containing protein 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFBI transforming growth factor, beta-induced, 68kDa
TGM2 transglutaminase 2
TM7SF2 transmembrane 7 superfamily member 2
TMEM97 transmembrane protein 97
TMSB15A thymosin beta 15a
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
TPBG trophoblast glycoprotein
TPCN1 two pore segment channel 1
TPD52L1 tumor protein D52-like 1
TPGS2 tubulin polyglutamylase complex subunit 2
TPM2 tropomyosin 2 (beta)
TPX2 TPX2, microtubule-associated
TRAK2 trafficking protein, kinesin binding 2
TSPAN8 tetraspanin 8
UBE2S ubiquitin-conjugating enzyme E2S
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican
WDR61 WD repeat domain 61
WNT5A wingless-type MMTV integration site family, member 5A
WRB tryptophan rich basic protein
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZMAT3 zinc finger, matrin-type 3
ZNF451 zinc finger protein 451
Funding