BRD-K04546108_JAK3 Inhibitor VI_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

78 genes differentially expressed following the BRD-K04546108_JAK3 Inhibitor VI_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANKRD36B ankyrin repeat domain 36B
AREG amphiregulin
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BLNK B-cell linker
CAPG capping protein (actin filament), gelsolin-like
CD44 CD44 molecule (Indian blood group)
CXCL10 chemokine (C-X-C motif) ligand 10
DSE dermatan sulfate epimerase
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOPX HOP homeobox
IGHD immunoglobulin heavy constant delta
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV3-19 immunoglobulin lambda variable 3-19
PBX1 pre-B-cell leukemia homeobox 1
PHACTR2 phosphatase and actin regulator 2
PPAP2B phosphatidic acid phosphatase type 2B
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
REEP1 receptor accessory protein 1
RSU1 Ras suppressor protein 1
TSPAN5 tetraspanin 5
TXNIP thioredoxin interacting protein
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACLY ATP citrate lyase
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
CBR3 carbonyl reductase 3
CCDC85B coiled-coil domain containing 85B
CD320 CD320 molecule
CDK19 cyclin-dependent kinase 19
CTSZ cathepsin Z
CXCL14 chemokine (C-X-C motif) ligand 14
DCXR dicarbonyl/L-xylulose reductase
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GDF15 growth differentiation factor 15
GPAA1 glycosylphosphatidylinositol anchor attachment 1
GSTZ1 glutathione S-transferase zeta 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
KDM5D lysine (K)-specific demethylase 5D
KIF20A kinesin family member 20A
LBR lamin B receptor
LDLR low density lipoprotein receptor
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MSMO1 methylsterol monooxygenase 1
NIPSNAP1 nipsnap homolog 1 (C. elegans)
PCOLCE procollagen C-endopeptidase enhancer
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
PLK1 polo-like kinase 1
PTS 6-pyruvoyltetrahydropterin synthase
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPL36 ribosomal protein L36
RPS4Y1 ribosomal protein S4, Y-linked 1
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMS spermine synthase
SOX9 SRY (sex determining region Y)-box 9
ST7 suppression of tumorigenicity 7
SUZ12 SUZ12 polycomb repressive complex 2 subunit
TARS threonyl-tRNA synthetase
TFF3 trefoil factor 3 (intestinal)
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TM7SF2 transmembrane 7 superfamily member 2
UBE2C ubiquitin-conjugating enzyme E2C
VLDLR very low density lipoprotein receptor
Funding