BRD-K04833372_GSK-1904529A_HME1_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-K04833372_GSK-1904529A_HME1_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADD3 adducin 3 (gamma)
AQP3 aquaporin 3 (Gill blood group)
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
BMP4 bone morphogenetic protein 4
BRD8 bromodomain containing 8
C10ORF10 chromosome 10 open reading frame 10
C1QB complement component 1, q subcomponent, B chain
C1R complement component 1, r subcomponent
C7 complement component 7
CCNG2 cyclin G2
CD163 CD163 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFD complement factor D (adipsin)
CFI complement factor I
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTH cystathionine gamma-lyase
DCN decorin
DPP4 dipeptidyl-peptidase 4
DUSP1 dual specificity phosphatase 1
EFNA1 ephrin-A1
ETV1 ets variant 1
FBLN1 fibulin 1
FGG fibrinogen gamma chain
FZD7 frizzled class receptor 7
GBP2 guanylate binding protein 2, interferon-inducible
HBP1 HMG-box transcription factor 1
HOXA5 homeobox A5
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IRS2 insulin receptor substrate 2
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KDM3A lysine (K)-specific demethylase 3A
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
METTL7A methyltransferase like 7A
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NELL2 NEL-like 2 (chicken)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PRKCH protein kinase C, eta
PTN pleiotrophin
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
STOM stomatin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSC22D3 TSC22 domain family, member 3
USP6NL USP6 N-terminal like
VAMP5 vesicle-associated membrane protein 5
VSIG4 V-set and immunoglobulin domain containing 4

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AK1 adenylate kinase 1
CCNE2 cyclin E2
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CLDN3 claudin 3
CRABP1 cellular retinoic acid binding protein 1
DARS aspartyl-tRNA synthetase
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
IL1B interleukin 1, beta
JMJD6 jumonji domain containing 6
MAT2A methionine adenosyltransferase II, alpha
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NQO1 NAD(P)H dehydrogenase, quinone 1
PER2 period circadian clock 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PNN pinin, desmosome associated protein
PPIF peptidylprolyl isomerase F
PROM1 prominin 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAD51C RAD51 paralog C
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCGB2A1 secretoglobin, family 2A, member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SFRP1 secreted frizzled-related protein 1
SPRR1A small proline-rich protein 1A
TFF3 trefoil factor 3 (intestinal)
VCAN versican
Funding