BRD-K04833372_GSK-1904529A_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K04833372_GSK-1904529A_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOD apolipoprotein D
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C1RL complement component 1, r subcomponent-like
CD44 CD44 molecule (Indian blood group)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHN1 chimerin 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DST dystonin
EGR1 early growth response 1
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
GUSBP3 glucuronidase, beta pseudogene 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HNMT histamine N-methyltransferase
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KDM3A lysine (K)-specific demethylase 3A
KIAA1598
LAMP2 lysosomal-associated membrane protein 2
LDLR low density lipoprotein receptor
LMO2 LIM domain only 2 (rhombotin-like 1)
LYN LYN proto-oncogene, Src family tyrosine kinase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MANSC1 MANSC domain containing 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MEIS2 Meis homeobox 2
NOV nephroblastoma overexpressed
NR2F2 nuclear receptor subfamily 2, group F, member 2
PDGFD platelet derived growth factor D
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PNRC1 proline-rich nuclear receptor coactivator 1
PROM1 prominin 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RHOBTB3 Rho-related BTB domain containing 3
RIN2 Ras and Rab interactor 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE6 ribonuclease, RNase A family, k6
RND3 Rho family GTPase 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SCYL3 SCY1-like 3 (S. cerevisiae)
SEPT6 septin 6
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRGN serglycin
STK38L serine/threonine kinase 38 like
TMC5 transmembrane channel-like 5
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSC22D1 TSC22 domain family, member 1
TUBA1A tubulin, alpha 1a
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
AK1 adenylate kinase 1
AKAP12 A kinase (PRKA) anchor protein 12
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
CA12 carbonic anhydrase XII
CALCA calcitonin-related polypeptide alpha
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CYBA cytochrome b-245, alpha polypeptide
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1 eukaryotic translation initiation factor 1
EIF5A eukaryotic translation initiation factor 5A
FABP5 fatty acid binding protein 5 (psoriasis-associated)
G0S2 G0/G1 switch 2
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPX3 glutathione peroxidase 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ITM2A integral membrane protein 2A
KDM5D lysine (K)-specific demethylase 5D
KRT13 keratin 13, type I
KRT6A keratin 6A, type II
LRRN3 leucine rich repeat neuronal 3
MFAP4 microfibrillar-associated protein 4
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MXRA5 matrix-remodelling associated 5
NID2 nidogen 2 (osteonidogen)
RPS4Y1 ribosomal protein S4, Y-linked 1
SNX7 sorting nexin 7
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPRR3 small proline-rich protein 3
TMEM100 transmembrane protein 100
Funding