BRD-K04853698_LDN-193189_A549_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-K04853698_LDN-193189_A549_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHSG alpha-2-HS-glycoprotein
ALB albumin
APLP2 amyloid beta (A4) precursor-like protein 2
APOB apolipoprotein B
APOH apolipoprotein H (beta-2-glycoprotein I)
C3 complement component 3
CCL20 chemokine (C-C motif) ligand 20
CD44 CD44 molecule (Indian blood group)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
CHEK2 checkpoint kinase 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COLEC12 collectin sub-family member 12
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXADR coxsackie virus and adenovirus receptor
CXCL5 chemokine (C-X-C motif) ligand 5
DMBT1 deleted in malignant brain tumors 1
FGA fibrinogen alpha chain
FGG fibrinogen gamma chain
FKBP11 FK506 binding protein 11, 19 kDa
HIPK1 homeodomain interacting protein kinase 1
HP haptoglobin
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGFBP4 insulin-like growth factor binding protein 4
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IL1RN interleukin 1 receptor antagonist
KCTD12 potassium channel tetramerization domain containing 12
KLF9 Kruppel-like factor 9
KRT10 keratin 10, type I
LDLR low density lipoprotein receptor
LMO4 LIM domain only 4
MTF2 metal response element binding transcription factor 2
PER2 period circadian clock 2
POU2AF1 POU class 2 associating factor 1
RBP4 retinol binding protein 4, plasma
REG3A regenerating islet-derived 3 alpha
S100A8 S100 calcium binding protein A8
SEPP1 selenoprotein P, plasma, 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLPI secretory leukocyte peptidase inhibitor
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TM4SF1 transmembrane 4 L six family member 1
TSPAN8 tetraspanin 8
TUBB2A tubulin, beta 2A class IIa
UNC13B unc-13 homolog B (C. elegans)
VCAN versican
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ADAM19 ADAM metallopeptidase domain 19
ADGRG1 adhesion G protein-coupled receptor G1
AMIGO2 adhesion molecule with Ig-like domain 2
BAMBI BMP and activin membrane-bound inhibitor
CAV2 caveolin 2
CCDC92 coiled-coil domain containing 92
CCL5 chemokine (C-C motif) ligand 5
CDC42 cell division cycle 42
CDH3 cadherin 3, type 1, P-cadherin (placental)
CLU clusterin
COL2A1 collagen, type II, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL5A2 collagen, type V, alpha 2
CXCL10 chemokine (C-X-C motif) ligand 10
DIO2 deiodinase, iodothyronine, type II
EIF5A eukaryotic translation initiation factor 5A
EPHB2 EPH receptor B2
FBN2 fibrillin 2
GPER1 G protein-coupled estrogen receptor 1
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITGAV integrin, alpha V
KRT7 keratin 7, type II
LBH limb bud and heart development
LRRN3 leucine rich repeat neuronal 3
MET MET proto-oncogene, receptor tyrosine kinase
PLAT plasminogen activator, tissue
PTHLH parathyroid hormone-like hormone
RGS3 regulator of G-protein signaling 3
RHOBTB3 Rho-related BTB domain containing 3
S100B S100 calcium binding protein B
SATB1 SATB homeobox 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
TARP TCR gamma alternate reading frame protein
TNS3 tensin 3
TOR1A torsin family 1, member A (torsin A)
TRIL TLR4 interactor with leucine-rich repeats
Funding