BRD-K04853698_LDN-193189_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-K04853698_LDN-193189_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAK1 AP2 associated kinase 1
ABHD4 abhydrolase domain containing 4
AQP3 aquaporin 3 (Gill blood group)
ARHGAP29 Rho GTPase activating protein 29
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C1S complement component 1, s subcomponent
CAB39 calcium binding protein 39
CASP7 caspase 7, apoptosis-related cysteine peptidase
CXCL14 chemokine (C-X-C motif) ligand 14
CYR61 cysteine-rich, angiogenic inducer, 61
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
EGF epidermal growth factor
EPAS1 endothelial PAS domain protein 1
F13A1 coagulation factor XIII, A1 polypeptide
FAM134B family with sequence similarity 134, member B
GBP1 guanylate binding protein 1, interferon-inducible
GEM GTP binding protein overexpressed in skeletal muscle
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IFI27 interferon, alpha-inducible protein 27
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
L1CAM L1 cell adhesion molecule
LPIN1 lipin 1
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSN moesin
MT1X metallothionein 1X
MTUS1 microtubule associated tumor suppressor 1
MX1 MX dynamin-like GTPase 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
PALLD palladin, cytoskeletal associated protein
PRRC2C proline-rich coiled-coil 2C
RAP1GAP RAP1 GTPase activating protein
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RND3 Rho family GTPase 3
SAMD4A sterile alpha motif domain containing 4A
SAT1 spermidine/spermine N1-acetyltransferase 1
SEC61G Sec61 gamma subunit
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNX11 sorting nexin 11
SOD2 superoxide dismutase 2, mitochondrial
TMEM45A transmembrane protein 45A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TUBB2A tubulin, beta 2A class IIa
TXNDC9 thioredoxin domain containing 9
WSB1 WD repeat and SOCS box containing 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADARB1 adenosine deaminase, RNA-specific, B1
ADIRF adipogenesis regulatory factor
AKR1C3 aldo-keto reductase family 1, member C3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
APLP2 amyloid beta (A4) precursor-like protein 2
CKB creatine kinase, brain
CSTA cystatin A (stefin A)
CXCL3 chemokine (C-X-C motif) ligand 3
FBP1 fructose-1,6-bisphosphatase 1
G0S2 G0/G1 switch 2
GJA1 gap junction protein, alpha 1, 43kDa
GPD1L glycerol-3-phosphate dehydrogenase 1-like
HSDL2 hydroxysteroid dehydrogenase like 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
ISYNA1 inositol-3-phosphate synthase 1
LAPTM4B lysosomal protein transmembrane 4 beta
LOXL1 lysyl oxidase-like 1
LTA4H leukotriene A4 hydrolase
MCM2 minichromosome maintenance complex component 2
MET MET proto-oncogene, receptor tyrosine kinase
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
PEG10 paternally expressed 10
PKM pyruvate kinase, muscle
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCD protein kinase C, delta
PTGDS prostaglandin D2 synthase 21kDa (brain)
RBP4 retinol binding protein 4, plasma
RFX5 regulatory factor X, 5 (influences HLA class II expression)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
TPM2 tropomyosin 2 (beta)
VCAN versican
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