BRD-K04887706_AKT-inhibitor-1-2_MCF7_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_MCF7_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
ARL4C ADP-ribosylation factor-like 4C
ATP9A ATPase, class II, type 9A
BCL3 B-cell CLL/lymphoma 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNG2 cyclin G2
CD9 CD9 molecule
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
COLEC12 collectin sub-family member 12
CST3 cystatin C
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
DDIT4 DNA-damage-inducible transcript 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM63A family with sequence similarity 63, member A
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXN3 forkhead box N3
FOXO4 forkhead box O4
GLTSCR2 glioma tumor suppressor candidate region gene 2
GSN gelsolin
HBP1 HMG-box transcription factor 1
HLA-C major histocompatibility complex, class I, C
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGF1R insulin-like growth factor 1 receptor
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
KLHL24 kelch-like family member 24
MAP2K5 mitogen-activated protein kinase kinase 5
MMP9 matrix metallopeptidase 9
MT1M metallothionein 1M
NPDC1 neural proliferation, differentiation and control, 1
PHGDH phosphoglycerate dehydrogenase
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLAU plasminogen activator, urokinase
PLK2 polo-like kinase 2
PLVAP plasmalemma vesicle associated protein
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
QPCT glutaminyl-peptide cyclotransferase
RAB13 RAB13, member RAS oncogene family
RAP2A RAP2A, member of RAS oncogene family
RPS4Y1 ribosomal protein S4, Y-linked 1
SEPP1 selenoprotein P, plasma, 1
SMAD3 SMAD family member 3
TFF3 trefoil factor 3 (intestinal)
TGFBI transforming growth factor, beta-induced, 68kDa
TM4SF1 transmembrane 4 L six family member 1
TNS3 tensin 3
TSC22D3 TSC22 domain family, member 3
WDR45 WD repeat domain 45
YPEL5 yippee-like 5 (Drosophila)
ZBTB38 zinc finger and BTB domain containing 38

decreased expression

Symbol Name
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
BAG2 BCL2-associated athanogene 2
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAS Fas cell surface death receptor
FEN1 flap structure-specific endonuclease 1
GOLT1B golgi transport 1B
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KRT10 keratin 10, type I
MAGEA3 melanoma antigen family A3
MCM10 minichromosome maintenance complex component 10
POSTN periostin, osteoblast specific factor
PRDX2 peroxiredoxin 2
PRPF4 pre-mRNA processing factor 4
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
SFN stratifin
STK26 serine/threonine protein kinase 26
TIGAR TP53 induced glycolysis regulatory phosphatase
TLR4 toll-like receptor 4
TUBB2A tubulin, beta 2A class IIa
TUBG1 tubulin, gamma 1
YME1L1 YME1-like 1 ATPase
Funding