BRD-K04887706_AKT-inhibitor-1-2_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

61 genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA4 annexin A4
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTGF connective tissue growth factor
CXCL3 chemokine (C-X-C motif) ligand 3
EFNA1 ephrin-A1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ERBB3 erb-b2 receptor tyrosine kinase 3
F11R F11 receptor
FGFR1 fibroblast growth factor receptor 1
FOXO4 forkhead box O4
HLA-C major histocompatibility complex, class I, C
HNMT histamine N-methyltransferase
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
LCK LCK proto-oncogene, Src family tyrosine kinase
LXN latexin
LY75 lymphocyte antigen 75
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MTUS1 microtubule associated tumor suppressor 1
NANOG Nanog homeobox
NAV2 neuron navigator 2
NRCAM neuronal cell adhesion molecule
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBPMS RNA binding protein with multiple splicing
SAT1 spermidine/spermine N1-acetyltransferase 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SH3BGRL SH3 domain binding glutamate-rich protein like
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TRBC1 T cell receptor beta constant 1
UGCG UDP-glucose ceramide glucosyltransferase

decreased expression

Symbol Name
BID BH3 interacting domain death agonist
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CLIC3 chloride intracellular channel 3
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL1RN interleukin 1 receptor antagonist
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KRT6A keratin 6A, type II
MAGEA6 melanoma antigen family A6
MX1 MX dynamin-like GTPase 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
ODC1 ornithine decarboxylase 1
PPIF peptidylprolyl isomerase F
TLR4 toll-like receptor 4
TMEM47 transmembrane protein 47
TUBG1 tubulin, gamma 1
ZEB1 zinc finger E-box binding homeobox 1
Funding