BRD-K04887706_AKT-inhibitor-1-2_MDAMB231_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

56 genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_MDAMB231_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1C1 aldo-keto reductase family 1, member C1
C14ORF1 chromosome 14 open reading frame 1
CHRDL1 chordin-like 1
CLIC5 chloride intracellular channel 5
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
IGHM immunoglobulin heavy constant mu
INSIG1 insulin induced gene 1
KRT7 keratin 7, type II
LDLR low density lipoprotein receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MLPH melanophilin
MSMO1 methylsterol monooxygenase 1
NEBL nebulette
NIPSNAP1 nipsnap homolog 1 (C. elegans)
PIR pirin (iron-binding nuclear protein)
POU2AF1 POU class 2 associating factor 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGCE sarcoglycan, epsilon
SKAP2 src kinase associated phosphoprotein 2
SLC16A6 solute carrier family 16, member 6
SQLE squalene epoxidase
SREBF2 sterol regulatory element binding transcription factor 2
TGM2 transglutaminase 2
TMEM97 transmembrane protein 97
TRBC1 T cell receptor beta constant 1
TSC22D3 TSC22 domain family, member 3
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
CA2 carbonic anhydrase II
CDC20 cell division cycle 20
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COX11 COX11 cytochrome c oxidase copper chaperone
CREB1 cAMP responsive element binding protein 1
HIST1H4C histone cluster 1, H4c
KIAA0101 KIAA0101
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1
S100A10 S100 calcium binding protein A10
SPP1 secreted phosphoprotein 1
TNPO1 transportin 1
TSPYL5 TSPY-like 5
TYMS thymidylate synthetase
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
Funding