BRD-K04887706_AKT-inhibitor-1-2_PC3_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

65 genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_PC3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CETN2 centrin, EF-hand protein, 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
ERAP1 endoplasmic reticulum aminopeptidase 1
ESR1 estrogen receptor 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
MSLN mesothelin
MSMO1 methylsterol monooxygenase 1
NARFL nuclear prelamin A recognition factor-like
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCP4 Purkinje cell protein 4
PDZK1IP1 PDZK1 interacting protein 1
PRAF2 PRA1 domain family, member 2
PRUNE2 prune homolog 2 (Drosophila)
PXDN peroxidasin
PYCARD PYD and CARD domain containing
QPCT glutaminyl-peptide cyclotransferase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SH3YL1 SH3 and SYLF domain containing 1
SPP1 secreted phosphoprotein 1
SQLE squalene epoxidase

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK6 cyclin-dependent kinase 6
CHSY1 chondroitin sulfate synthase 1
CXCL14 chemokine (C-X-C motif) ligand 14
DSG2 desmoglein 2
EREG epiregulin
FKBP11 FK506 binding protein 11, 19 kDa
HES1 hes family bHLH transcription factor 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
KIF14 kinesin family member 14
KRT10 keratin 10, type I
LAMB1 laminin, beta 1
LRP4 low density lipoprotein receptor-related protein 4
MET MET proto-oncogene, receptor tyrosine kinase
MT1M metallothionein 1M
NAMPT nicotinamide phosphoribosyltransferase
NFIB nuclear factor I/B
POSTN periostin, osteoblast specific factor
SACS sacsin molecular chaperone
SATB2 SATB homeobox 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
TFPI2 tissue factor pathway inhibitor 2
WIF1 WNT inhibitory factor 1
Funding